Research interest(s)/area of expertise
- Inter-organelle contact sites
- Lipid trafficking, storage, and utilization
- Organization of metabolic networks
- Nutrient signaling
- Aging and metabolic disorders
- B.S., Biological Sciences, Lebanese University, Hadath, Lebanon (2007)
- M.Sc., Cell and Molecular Biology, American University of Beirut, Beirut, Lebanon (2009)
- Ph.D., Molecular Biophysics, Florida State University, Tallahassee FL (2015)
- Postdoctoral fellow, Cellular Metabolism, University of Texas Southwestern Medical Center, Dallas TX (2020)
Hanaa Hariri (2020). Topography and Functions of Membrane Contact Sites. Encyclopedia of Biological Chemistry 3rd Edition (Accepted).
N Ezgi Wood, Piya Kositangool, Hanaa Hariri, Ashley Marchand, Mike Henne (2020). Nutrient signaling, stress response, and interorganelle communication are non-canonical determinants of cell fate. Cell Reports. Vol 33, Issue 9.
Sanchari Datta, Jade Bowerman, Hanaa Hariri, Rupali Ugrankar, KaitlynM. Eckert, Chase Corley, Gonçalo Vale, Jeffrey G. McDonald, Mike Henne (2020). Snx14 proximity labeling reveals a role in saturated fatty acid metabolism and ER homeostasis defective in SCAR20 disease. Proceedings of the National Academy of Sciences 117 (52) 33282-33294.
Sean Rogers, Hanaa Hariri, Long Gui, N. Ezgi Wood, Natalie Speer, Daniela Nicastro, W. Mike Henne (2020). Glucose restriction drives spatial re-organization of mevalonate metabolism and liquid-crystalline lipid droplet biogenesis. Elife (In revision). Read on bioRxiv.
Mike Henne, Joel Goodman, Hanaa Hariri* (2020). Spatial compartmentalization of lipid droplet biogenesis. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1865, 158499. *Corresponding author.
Rupali Ugrankar, Jade Bowerman, Hanaa Hariri, Sanchari Datta, Sonia Gonzalez, Joseph Gonzalez, and W. Mike Henne (2019). Drosophila Snazarus regulates a lipid droplet sub-population at plasma membrane-droplet contacts in fat body adipocytes. Developmental Cell. 50: 557–572.
Hanaa Hariri, Natalie Speer, Jade Bowerman, Sanchari Datta, Sean Rogers, Ryan Feathers, Rupali Ugrankar, W. Mike Henne (2019). Mdm1 maintains endoplasmic reticulum homeostasis by spatially regulating fatty acid processing and lipid droplet biogenesis. Journal of Cell Biology. 218:1319-1334.
Sanchari Datta, Yang Liu, Hanaa Hariri, W. Mike Henne (2019). Cerebellar ataxia disease-associated Snx14 promotes lipid droplet growth at ER-droplet contacts. Journal of Cell Biology. 218:1335-1351.
Hanaa Hariri, Sean Rogers, Rupali Ugrankar, Yang Lydia Liu, J. Ryan Feathers, W. Mike Henne (2018). Lipid droplet biogenesis is spatially coordinated at yeast ER-lysosome contact sites in response to nutritional stress. EMBO Reports. 19: 57–72.
Dale Bryant, Yang Liu, Sanchari Datta, Hanaa Hariri, Glenn Anderson, Emma Peskett, Charalambos Demetriou, Marian Seda, Dagan Jenkins, Sergio Sousa, Peter Clayton, Maria Bitner-Glindzicz, Gudrun Moore, Mike Henne, Philip Stanier (2018). SNX14 mutations affect cholesterol metabolism at the endoplasmic reticulum in SCAR20. Human Molecular Genetics. 27:1927–1940.
Hanaa Hariri, Rupali Ugrankar, Yang Liu, and W. Mike Henne (2018). Inter-organelle ER-endolysosomal contact sites in metabolism and disease across evolution. Communicative and Integrative Biology. Review. 9(3):e1156278