Pei-Chung Lee

Pei-Chung Lee

Assistant Professor

 4137 Biological Sciences 

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Pei-Chung Lee


Biological Sciences

Research interest(s)/area of expertise

  • Host-pathogen interactions
  • Innate immunity
  • Microbiology/bateriology
  • Post-translational modifications


The laboratory is interested in infection strategies used by bacterial pathogens to cause diseases. We focus on studying the function of the effector kinases encoded by the emerging pathogen, Legionella pneumophila, and how these bacterial kinases hijack host pathways in immune cells to promote infection in its hosts.

Our team always welcomes motivated students from all backgrounds (graduate and undergraduate students) to join the lab and explore exciting areas of host-pathogen interactions with us. 

When contacting, please let us know why our lab research interests you and your learning goals in the research lab.


  • 2019: Postdoctoral Fellow, National Institutes of Health (Mentor: Dr. Matthias Machner)
  • 2014: Postdoctoral Scholar, Case Western Reserve University (Mentor: Dr. Arne Rietsch)
  • 2011: PhD, Case Western Reserve University (Mentor: Dr. Arne Rietsch)

Awards and grants

University Research Grant 2020-21, Wayne State University (Role: PI)

Selected publications

  • Pei-Chung Lee, Ksenia Beyrakhova, Caishuang Xu, Michal T. Boniecki, Mitchell H. Lee, Chisom J. Onu, Andrey M. Grishin, Matthias P. Machner, Miroslaw Cygler. (2020) Structural insight into a bacterial kinase-host activator complex that exploits the mammalian Hippo pathway. Proceedings of the National Academy of Sciences of the USA
  • Pei-Chung Lee and Matthias P. Machner. (2018) The Legionella effector kinase LegK7 hijacks the host Hippo pathway to promote infection. Cell Host & Microbe.
  • Pei-Chung Lee and Arne Rietsch. (2015) Fueling type III secretion. Trends in Microbiology.
  • Pei-Chung Lee, Stephanie Zmina, Charles M. Stopford, Jonida Toska, Arne Rietsch. (2014) Control of type III secretion activity and substrate specificity by the cytoplasmic regulatory protein PcrG. Proceedings of the National Academy of Sciences of the USA.

Google scholar publication list

Currently teaching

BIO7610/5310, Infections and Innate Immunity (Fall 2021)

Courses taught

BIO2200, Introductory Microbiology (Winter 2021)

BIO7610/5310, Infections and Innate Immunity (Fall 2020)

BIO8995 Graduate Seminar in Biology (Fall 2019)