4137 Biological Sciences
Research interest(s)/area of expertise
- Host-pathogen interactions
- Innate immunity
- Post-translational modifications
The laboratory is interested in infection strategies used by bacterial pathogens to cause diseases. We focus on studying the function of the effector kinases encoded by the emerging pathogen, Legionella pneumophila, and how these bacterial kinases hijack host pathways in immune cells to promote infection in its hosts.
- 2014-2019: Postdoctoral Fellow, National Institutes of Health
- 2011-2013: Postdoctoral Scholar, Case Western Reserve University
- 2006-2011: PhD, Case Western Reserve University
- Pei-Chung Lee and Matthias P. Machner. (2018) The Legionella effector kinase LegK7 hijacks the host Hippo pathway to promote infection. Cell Host & Microbe.
- Pei-Chung Lee and Arne Rietsch. (2015) Fueling type III secretion. Trends in Microbiology.
- Pei-Chung Lee, Stephanie Zmina, Charles M. Stopford, Jonida Toska, Arne Rietsch. (2014) Control of type III secretion activity and substrate specificity by the cytoplasmic regulatory protein PcrG. Proceedings of the National Academy of Sciences of the USA.