Research Interest/Area of Expertise
Developing and utilizing highly selective chemical reactions that are able to occur in living cells to track sugar signaling motifs in disease states characterized by altered sugar metabolism
Dr. Charlie Fehl is a synthetic chemical biologist. His training--spanning the Atlantic ocean at times (University of Michigan / University of Kansas / Universität Regensburg (Germany) / Oxford University (United Kingdom))--focused on chemical techniques in catalyst design, photochemistry, and biocatalysis. These were applied to solve problems in drug design, protein synthesis + modification, epigenetic protein-protein interactions, and understanding complex enzymatic networks. Researchers in the Fehl Lab will develop selective chemical and biochemical tools to unravel and treat complex problems in disease biology.
Education – Degrees, Licenses, Certifications
- B.S. University of Michigan, 2009
- Ph.D. University of Kansas, 2014
- Postdoctoral Research Associate, University of Oxford, UK, 2014-2018
- "Use of a tandem Prins/Friedel-Crafts reaction in the construction of the indeno-tetrahydropyridine core of the haouamine alkaloids: formal synthesis of (-)-haouamine A." Fenster, Erik; Fehl, Charlie; Aubé, Jeffrey. Org. Lett. 2011, 13, 2614. DOI: 10.1021/ol200725m
- "Overcoming product inhibition in catalysis of the intramolecular Schmidt reaction." Motiwala, Hashim F.; Fehl, Charlie; Li, Sze-Wan; Hirt, Erin E.; Porubsky, Patrick; Aubé, Jeffrey. J. Am. Chem. Soc. 2013, 135, 9000. DOI: 10.1021/ja402848c
- "Photocatalytic surface patterning of cellulose using diazonium salts and visible light." Schroll, Peter; Fehl, Charlie; Dankesreiter, Stefan; König, Burkhard. Org. Biomol. Chem. 2013, 11, 6510. DOI: 10.1039/c3ob40990b
- "Temperature dependence of turnover in a Sc(OTf)3-catalyzed intramolecular Schmidt reaction." Fehl, Charlie; Hirt, Erin. E.; Li, Sze-Wan; Aubé, Jeffrey. Tetrahedron Lett. 2015, 56, 3137. DOI: 10.1016/j.tetlet.2014.12.068
- "Proteins as templates for complex synthetic metalloclusters: towards biologically programmed heterogeneous catalysis." Fehl, Charlie; Davis, Benjamin G. Proc. Royal Soc. A: Math. Phys. Eng. Sci. 2016, 472, 20160078. DOI: 10.1098/rspa.2016.0078
- "Structure-based design of inhibitors with improved selectivity for steroidogenic cytochrome P450 17A1 over cytochrome P450 21A2." Fehl, Charlie; Vogt, Caleb; Yadav, Rahul; Li, Kelin; Scott, Emily E.; Aubé, Jeffrey. J. Med. Chem. 2018, 61, 4946. DOI: 10.1021/acs.jmedchem.8b00419
- "Functional screening and chemo-bioinformatic analysis allows rationalization and activity prediction within a broad protein family." Yang, Min*; Fehl, Charlie* [*equal contributors]; Lees, Karen V.; Lim, Eng-Kiat; Offen, Wendy; Davies, Gideon J.; Bowles, Dianna J.; Roberts, Stephen J.; Davis, Benjamin G. Nature Chemical Biology, Accepted (2018).
CHM 1240 Organic Chemistry 1, 4 credit hours, W2019
CHM 6270 Advances Bioorganic Chemistry & Drug Design, 3 credit hours, F2018