Charlie Fehl

Charlie Fehl

Assistant Professor

313-577-5667

313-577-8822 (fax)

charlie.fehl@wayne.edu

Chem 469

Curriculum vitae

Website(s)

https://fehl-lab.com

Social media

@FehlLab

@CharlieFehl

@CharlieFehl

Charlie Fehl

Department

Chemistry

Research interest(s)/area of expertise

  • Developing and utilizing highly selective chemical reactions that are able to occur in living cells to track sugar signaling motifs in disease states characterized by altered sugar metabolism

Research

Dr. Charlie Fehl is a synthetic chemical biologist. His training--spanning the Atlantic ocean at times (University of Michigan / University of Kansas / Universität Regensburg (Germany) / Oxford University (United Kingdom))--focused on chemical techniques in catalyst design, photochemistry, and biocatalysis. These were applied to solve problems in drug design, protein synthesis + modification, epigenetic protein-protein interactions, and understanding complex enzymatic networks. Researchers in the Fehl Lab will develop selective chemical and biochemical tools to unravel and treat complex problems in disease biology.

Education

  • B.S. University of Michigan, 2009
  • Ph.D. University of Kansas, 2014
  • Postdoctoral Research Associate, University of Oxford, UK, 2014-2018

Awards and grants

  •  University Research Grant (WSU, 2019-2020)

    Ebbing Faculty Development Award (WSU, 2020-2021)

     

Selected publications

  1. "Use of a tandem Prins/Friedel-Crafts reaction in the construction of the indeno-tetrahydropyridine core of the haouamine alkaloids: formal synthesis of (-)-haouamine A." Fenster, Erik; Fehl, Charlie; Aubé, Jeffrey. Org. Lett. 2011, 13, 2614. DOI: 10.1021/ol200725m
     
  2. "Overcoming product inhibition in catalysis of the intramolecular Schmidt reaction." Motiwala, Hashim F.; Fehl, Charlie; Li, Sze-Wan; Hirt, Erin E.; Porubsky, Patrick; Aubé, Jeffrey. J. Am. Chem. Soc. 2013, 135, 9000. DOI: 10.1021/ja402848c
     
  3. "Photocatalytic surface patterning of cellulose using diazonium salts and visible light." Schroll, Peter; Fehl, Charlie; Dankesreiter, Stefan; König, Burkhard. Org. Biomol. Chem. 2013, 11, 6510. DOI: 10.1039/c3ob40990b
     
  4. "Temperature dependence of turnover in a Sc(OTf)3-catalyzed intramolecular Schmidt reaction." Fehl, Charlie; Hirt, Erin. E.; Li, Sze-Wan; Aubé, Jeffrey. Tetrahedron Lett. 2015, 56, 3137. DOI: 10.1016/j.tetlet.2014.12.068
     
  5. "Proteins as templates for complex synthetic metalloclusters: towards biologically programmed heterogeneous catalysis." Fehl, Charlie; Davis, Benjamin G. Proc. Royal Soc. A: Math. Phys. Eng. Sci. 2016, 472, 20160078. DOI: 10.1098/rspa.2016.0078
     
  6. "Structure-based design of inhibitors with improved selectivity for steroidogenic cytochrome P450 17A1 over cytochrome P450 21A2." Fehl, Charlie; Vogt, Caleb; Yadav, Rahul; Li, Kelin; Scott, Emily E.; Aubé, Jeffrey. J. Med. Chem. 2018, 61, 4946. DOI: 10.1021/acs.jmedchem.8b00419
     
  7. "Functional screening and chemo-bioinformatic analysis allows rationalization and activity prediction within a broad protein family." Yang, Min*; Fehl, Charlie* [*equal contributors]; Lees, Karen V.; Lim, Eng-Kiat; Offen, Wendy; Davies, Gideon J.; Bowles, Dianna J.; Roberts, Stephen J.; Davis, Benjamin G. Nature Chemical Biology, Accepted (2018).
  8. "Light-driven post-translational installation of reactive protein side chains." Brian Josephson*, Charlie Fehl*, Patrick Iseneggar*, Simon Nadal, Tom H Wright, Adeline W J Poh, Ben J Bower, Andrew M Giltrap, Lifu Chun, Christopher Batchelor-McAuley, Grace Roper, Oluwatobi Arisa, Jeroen B I Sap, Akane Kawamura, Andrew J Baldwin, Shabaz Mohammed, Richard G Compton, Veronique Gouverneur, Benjamin G Davis. Nature, 585, 530-537 (2020).
  9. "Chemical Synthesis and Biological Applications of O-GlcNAcylated Peptides and Proteins." Jessica M Groenevelt, Daniel J Corey, Charlie Fehl.

     

 

Currently teaching

  • CHM 1240 Organic Chemistry 1, 4 credit hours, W2021

     

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Courses taught

CHM 6270/7270 Advanced Bioorganic Chemistry & Drug Design, 3 credit hours, F2020
CHM 6680/7680Clinical and Molecular Aspects of Cancer (team-teaching), 3 credit hours, F2020

CHM 6270/7270 Advanced Bioorganic Chemistry & Drug Design, 3 credit hours, F2018

CHM 1240 Organic Chemistry 1, 4 credit hours, W2019

 


CHM 6270/7270 Advanced Bioorganic Chemistry & Drug Design, 3 credit hours, F2019
CHM 1240 Organic Chemistry 1, 4 credit hour, W2020
CHM 5998 Honors Thesis Research in Chemistry, 2-4 credit hours, W2020
CHM 5999 Research in Chemistry, 2-4 credit hours, W2020