Jennifer L. Stockdill
Jennifer L. Stockdill
Research Interest/Area of Expertise
Synthesis of natural products, methodology development, synthesis and selective functionalization of peptides and proteins
Research in the Stockdill group will be focused on the design of elegant and efficient strategies for the synthesis of complex natural products and for the synthesis and manipulation of proteins and related structures. Through these efforts, we will explore chemical reactivity and develop new reaction methods.
Target-Inspired Synthesis and Biological Studies of Natural Products
Natural products have served as inspirational targets for synthetic chemists for decades, with structural challenges driving the development of novel methods for the construction of C-C, C-N, and C-O bonds. Meanwhile, they have also been the most consistently successful source of lead targets for pharmaceutical development over the last half-century. However, many promising targets are neglected due to their apparent complexity. Our research will focus on developing rapid, convergent, and innovative approaches to these challenging structures. Subsequently, the synthetic intermediates, targets, and analogs will be tested for novel biological activity. We will then embark on studies to determine the mechanism of action of these compounds in an effort to not only provide novel potential pharmaceuticals, but also to shed light on the biological pathways involved in particular disease states.
Synthesis, Manipulation, and Biological Evaluation of Proteins and Mini-Proteins
While small molecule natural products are advantageous drug targets, owing to their stability, relative accessibility, and rigidity, peptide and protein-derived treatments offer unique benefits including their high modularity, exquisite selectivity for their cellular targets, and generally favorable toxicity profiles. Our research in this area will begin by addressing serious challenges in the synthetic accessibility of these biomolecules, such as how to control the folding of synthetic proteins. We will also develop methods for the direct functionalization of peptides and proteins, which will enable cross-linking experiments, structure-function studies, and the interrogation of protein function. Finally, synthetic analogs of medically important proteins will be generated to modify their selectivity, stability and pharmacodynamics.
Education – Degrees, Licenses, Certifications
- BS Virginia Tech 2003
- PhD California Institute of Technology (Stoltz) 2009
- NIH Postdoctoral Fellow, Memorial Sloan-Kettering Cancer Center 2009-2012
Yang, Y.Y.; Ibrahim, A. A.; Hashemi, P.;* Stockdill, J. L.* Real-Time, Selective Detection of Copper(II) using Ionophore-Grafted Carbon-Fiber Microelectrodes. Anal. Chem. 2016, Accepted.
Yang, Y.Y.; Ibrahim, A. A.; Stockdill, J. L.;* Hashemi, P.* A Density-Controlled Scaffolding Strategy for Covalent Functionalization of Carbon-Fiber Microelectrodes. Anal. Methods 2015, 7, 7352-7357. Part of the 2015 Emerging Investigators Themed Collection
Stockdill, J. L.;* Lopez, A. M.; Ibrahim, A. A. Toward the ABCD Core of the Calyciphylline A-Type Daphniphyllum Alkaloids: Solvent non-Innocence in Neutral Aminyl Radical Cyclizations. Tetrahedron Lett. 2015, 3503-3506. Invited Submission to Symposium in Print in Memory of Harry Wasserman.
Ibrahim, A. A.; Golonka, A. N.; Lopez, A. M.; Stockdill, J. L.* Rapid Access to the Heterocyclic Core of the Calyciphylline A and Daphnicyclidin A-type Daphniphyllum Alkaloids via Tandem Cyclization of a Neutral Aminyl Radical. Org. Lett. 2014, 16, 1072-1075. Highlighted in Doug Taber's Organic Chemistry Highlights