Young Hoon Ahn
Young Hoon Ahn
Research Interest/Area of Expertise
Oxidative protein modification, cytoprotection, chemical biology, protein semi-synthesis, small molecule screening, fluorescent probes
The research interest in my laboratory lies in the field of chemical biology. Our goals are 1) to understand the significance of oxidative protein modifications that occur in redox signaling or oxidative stress and 2) to develop small molecules that can provide cellular protection against oxidative damages. To this end, we take multidisciplinary approach at the interface of chemistry and biology, including synthetic organic chemistry, protein biochemistry, and cell biology.
Education – Degrees, Licenses, Certifications
- B.S., POSTECH (Pohang University of Science and Technology), 1999
- M.S., POSTECH (Pohang University of Science and Technology), 2001
- Ph.D., New York University, 2007
- Postdoctoral Fellow, Johns Hopkins University School of Medicine, 2008-2012
Samarasinghe, K. T. G., Munkanatta Godage, D. N. P., Zhou, Y., Ndombera, F. T., Weerapana, E., Ahn, Y. H.* Clickable Glutathione Approach for Identification of Protein Glutathionylation in Response to Glucose Metabolism. Mol. Biosyst. 2016, In Press.
Ndombera, F. T., VanHecke, G. C., Nagi, S., Ahn, Y. H.* Carbohydrate-based Inducers of Cellular Stress for Targeting Cancer Cells. Bioorg. Med. Chem. Lett. 2016, 26, 1452-1456.
Samarasinghe, K. T. G., Ahn, Y. H.* Synthesizing Clickable Glutathione by Glutathione Synthetase Mutant for Detecting Protein Glutathionylation. SynLett. 2015, 26, 285-293.
Samarasinghe, K. T. G., Munkanatta Godage, D. N. P., VanHecke, G. C., Ahn, Y. H.* Metabolic Synthesis of Clickable Glutathione for Chemoselective Detection of Glutathionylation. J. Am. Chem. Soc. 2014, 136, 11566-11569.
Zhang, Y., Naidu, S. D., Samarasinghe, K. T. G., VanHecke, G. C., Pheely, A., Boronina, T. N., Cole, R. N., Benjamin, I. B., Cole, P. A., Ahn, Y. H.*, Dinkova-Kostova, A. T.* Inhibition of HSP90 by sulfhydryl-reactive sulfoxythiocarbamates. Brit. J. Cancer. 2014, 110, 71-82.
CHM 5600 Survey: Biochemistry, 3 credit hours W2019
CHM 7600 Structure & Function: Biomolecules, 3 credit hours W2019
CHM 6610 Biological Chemistry Lab, 3 credit hours F2018