Marianna Sadagurski

Marianna Sadagurski

Research interest(s)/area of expertise

• Hypothalamic regulation of metabolism in health and disease

• Pollution and hypothalamic inflammation

• Anti-aging interventions and aging brain

• Maternal environment, metabolic disease and aging

Research

Our research program focuses on the hypothalamic regulation of metabolism in states of environmental stress, obesity and aging. The hypothalamus integrates information from the liver, muscle, fat and other organs and orchestrates whole-body metabolic homeostasis. We study signaling pathways operating in hypothalamic neurons and glia cells (astrocytes and microglia), which are highly relevant to the control of systemic metabolism and the age-associated changes in the glia-neuron interactions.

Our lab employs a multi-disciplinary approach to manipulate brain neurocircuits and nutrient-sensing pathways using cutting-edge molecular, genetics and metabolic assessments in rodents. 

Current projects in the lab:

• The role of hypothalamic neuroinflammation in the aging brain
• Exposure to air pollution is a trigger for hypothalamic inflammation and metabolic disease
• The effect of perinatal exposure to VOC on hypothalamic development, neuroinflammation and whole-body metabolism in the offspring
• Hypothalamic neuroendocrine axis in aging and metabolism

For more details visit s.wayne.edu/sadagurski-lab.

Education

• Ph.D., Tel Aviv University, Israel, 2000-2006
• Postdoc, Harvard Medical School, HHMI, 2006-2012

Awards and grants

Ongoing research support

• ADA 1-18-JDF-063 
• R01ES033171
• RF1AG078170
• R01DK129681 
  
• MDRC P30DK092926
• Impetus

News mentions

• Wayne State study links type 2 diabetes and air pollution
• Study links air pollution exposure to type 2 diabetes susceptibility
• Wayne State receives funding to explore intergenerational impacts of benzene exposure

Selected publications

• NIH

Courses taught by Marianna Sadagurski

Fall Term 2025 (future)

• BIO5660 - Neural Signaling in Health and Disease
• BIO7660 - Neural Signaling in Health and Disease

Fall Term 2023

• BIO5660 - Neural Signaling in Health and Disease
• BIO7660 - Neural Signaling in Health and Disease