Department of Biological Sciences
Research interest(s)/area of expertise
- Comparative genomics
- Genes and networks
- Mitochondrial genomes
Our primary research interest is to develop a better understanding of the highly dynamic genomic changes and their corresponding functional consequences. To accomplish this research, we conduct comparative genomic studies using next-generation sequencing, experimental and bioinformatics approaches. Much of our published work has been carried out on bacteria, yeast and fungi.
We plan to continue the investigation of molecular mechanisms underlying variable genome architecture.
1) Evolution of genes and networks.
2) Mechanism of mutations.
- Certificate in Effective College Instruction (2018)
- Ph.D. Bioinformatics, McMaster University
- M.Sc. Microbiology, NanKai University
- B. Sc. Microbiology, NanKai University
Awards and grants
NSERC Postdoctoral Fellow (2009-2011)
Group members are in bold face
Undergraduate students are underlined
- (40) Nguyen DT#, Wu B#, Xiao S#, Hao W* (2020) Evolution of a record-setting AT-rich genome: indel mutation, recombination, and substitution bias. Genome Biology and Evolution 12:2344-2354. [Pubmed] [Reprint] (39) Nguyen DT, Wu B, Long H*, Zhang N, Patterson C, Simpson S, Morris K, Thomas WK, Lynch M, Hao W* (2020) Variable spontaneous mutation and loss of heterozygosity among heterozygous genomes in yeast. Molecular Biology and Evolution 37:3118-3130. [Pubmed] [Reprint]
- (39) Nguyen DT, Wu B, Long H*, Zhang N, Patterson C, Simpson S, Morris K, Thomas WK, Lynch M, Hao W* (2020) Variable spontaneous mutation and loss of heterozygosity among heterozygous genomes in yeast. Molecular Biology and Evolution 37:3118-3130. [Pubmed] [Reprint]
- (38) Plazyo O, Hao W*, Jin JP* (2020) The absence of Calponin 2 in rabbit suggests caution in choice of animal model. Frontiers in Bioengineering and Biotechnology doi: 10.3389/fbioe.2020.00042 [Pubmed] [Reprint]
- (37) Wu B, Hao W* (2019) Mitochondrial-encoded endonucleases drive recombination of protein coding genes in yeast. Environmental Microbiology 21:4233-4240. [Pubmed] [Reprint]
- (36) Su HJ, Barkman TJ, Hao W, Jones SS, Naumann J, Skippington E, Wafula EK, Hu JM, Palmer JD, dePamphilis CW* (2019) A novel genetic code and record-setting AT-richness in the highly reduced plastid genome of the holoparasitic plant Balanophora. Proc Natl Acad Sci U S A 116: 934-943. [Pubmed] [Reprint]
- (35) Mafiz A, Perera LN, He Y, Zhang W, Xiao S, Hao W, Sun S, Zhou K, Zhang Y* (2018) A case study on soil antibiotic resistome in an urban community garden. International Journal of Antimicrobial Agents 52:241-250. [Pubmed] [Reprint]
- (34) Xiao S#, Nguyen DT#, Wu B, Hao W* (2017) Genetic drift and indel mutation in the evolution of yeast mitochondrial genome size. Genome Biology and Evolution 9:3088-3099. [Pubmed] [Reprint]
- (33) Wu B, Macielog AI, Hao W* (2017) Origin and spread of spliceosomal introns: insights from the fungal clade Zymoseptoria. Genome Biology and Evolution 9:2658-2667. [Pubmed] [Reprint]
- (32) Ha SW, Ju D, Hao W, Xie Y* (2016) Rapidly translated polypeptides are preferred substrates for cotranslational protein degradation. Journal of Biological Chemistry 291:9827-9834. [Pubmed] [Reprint]
- (31) Bhagwat AS*, Hao W, Townes JP, Lee H, Tang H, Foster PL (2016) Strand-biased cytosine deamination at the replication fork causes cytosine to thymine mutations in Escherichia coli. Proc Natl Acad Sci U S A 113:2176-2181. [Pubmed] [Reprint]
- (30) Wu B, Buljic A, Hao W* (2015) Extensive horizontal transfer and homologous recombination generate highly chimeric mitochondrial genomes in yeast. Molecular Biology and Evolution 32:2559-2570. [Pubmed] [Reprint]
- (29) Wu B, Hao W* (2015) A dynamic mobile DNA family in the yeast mitochondrial genome. G3: Genes | Genomes | Genetics 5:1273-1282. [Pubmed] [Reprint]
- BIO1500 (BUILD)
- BIO1510 (BUILD)
- BIO4200 (2013-2020)
- BIO6994 (2020)