Takeshi Sakamoto

Takeshi Sakamoto

Associate Professor in Physics
Adjunct Professor in Department of Physiology, School of Medicine, Wayne State University



 Room 287 in Physics Building



Takeshi Sakamoto

Research interest(s)/area of expertise

Molecular motors: Myosin, Kinesin, & Dynein; Kinetics study of Heart & Muscle; Hearng loss; Migration of Cancer cells, 


His labs focus on following reserach areas: molecular motors, single molecule imaging, force measurement by Optical trap, Cell mechanics, Cancer research, The simulation of ensemble works, Solution kinetics.

 More information, please go to http://takeshisakamotolabs.com/



Awards and grants

2009 ~ 2012 K99/R00 NIH Pathway to Indipendent award

2015 ~ 2019 NSF Career Developmetal Award

Selected publications

 1: Gunther LK., Feng H-Z., Wei H., Raupp J., Jin J.-P., Sakamoto T*., Effect of N-terminal
     Extension of Cardiac Troponin I on the Ca2+ Regulation of ATP-binding and ADP
     Dissociation of Myosin II in Native Cardiac Myofibrils. Biochemistry, 2016, 55(12), 1887-
2: Fang J.,Liu M., Zhang X., Sakamoto T., Taatjes D.J., Jena B.P., Sun F., Woods J., Bryson
     T., Kowluru K., and Chen X., COPII-Dependent ER Export: A Critical Component of
     Insulin Biogenesis and -Cell ER Homeostasis. Molecular Endocrinology, 2015, 29(8),
3: Bao J., Wang S., Gunther L.K., Kitairi S., Li C., and Sakamoto T.*, The Actin-bundling
    Protein TRIOBP-4 and -5 Promotes the Motility of Pancreatic Cancer Cells.
    Cancer letter, S0304-3835 (14)00433-9
4: Gunther L.K., Furuta K., Boa J., Urbanowski M.K., Kojima H., Whie H.D., and
    Sakamoto T.*, Coupling of two non-processive myosin 5c dimers enables processive
    stepping along Actin filament. Scientific Reports, 2014, 9(4), 4907
5: Bao J., Gunther L.K., Bielski E., Bachhawat A., Thirumurugan T, Kitajiri S., and
    Sakamoto T.*, R1 motif is the major actin-binding domain of TRIOBP-4, 2012,
    Biochemistry, 2013, 52(31), 5256-4
6: Bao J., Huck D., Gunther L.K., Sellers J.R., and Sakamoto T.*, Actin structure-
    Dependent stepping of myosin 5a and 10 during processive movement. PLoS One, 2013,
   8(9), e74936
7: Nagi N.T., Saikat C., Harami G.M., Sellers J.R., Sakamoto T., and Kovacs M.,
   A subdomain interaction at the base of the lever allosterically tunes the mechanochemical
   mechanism of myosin 5a. PLoS One, 2013, 8, e62640
8: Martina J.A., Wu X.S., Catalfamo M., Sakamoto T., Yi C., Hammer J.A. 3rd, Imaging of
    Lytic granule exocytosis in CD8(+) cytotoxic T lymphocytes reveals a modified form of
    Full fusion. Cell Immunol., 2011, 271(2), 267-79
9: Nagy N.T., Sakamoto T., Takacs B., Gyimesi M., Bikadi Z., Sellers J.R., and Kovacs M.,
    Functional adaptation of the switch-2 nucleotide sensor enables rapid processive
    Translocation by myosin-5, FASEB J, 2010, 24(11), 4480-90
10: Kitajiri S., Sakamoto T., Belyantseva I.A., Goodyear R.J., Stepanyan R., Fujiwara I.,
    Bird J.E., Riazuddin S., Riazuddin S., Ahmed Z.M., Hinshaw J.E., Sellers J.R., Bartles
    J.R., Hammer J.A. 3rd, Richardson G.P., Griffith A.J., Forlenkov G.I., and Friedman T.B.,
    TRIOBP is a novel Actin-bundling protein required for rootlet formation and rigidity of
    hail cell stereocilia. Cell, 2010, 141(5), 786-98.
11: Oke O., Burgess S.A., Forgacs E., Knight P.J., Sakamoto T., Sellers J.R., White H., and
    Trinich J., Influence of lever structure on myosin 5a walking,
    Proc. Natl. Acad. Sci. U.S.A., 2010, 107, 2509-14

Currently teaching

 PHY 5340

Courses taught

General Physics (Physics I);   PHY2130: W17
General Physics (Physics II):  PHY2140: W13, W14, W15, W16, F19, F20
Biological Physics:                       PHY5750: F11, F12, F13, F14, F15

Optics PHY5340: W19, W20, W21
Thermodynamics and Statistical Physics:   PHY6500: F16
Research methods in Biomedical Physics: PHY6780: W10, W11, W12