Anthony Cacace, Ph.D.

Anthony Cacace, Ph.D.

Professor
Audiology

313.577.6753

313.577.8885 (fax)

cacacea@wayne.edu

 202.31 Rackham Building

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Websites

www.clas.wayne.edu/cacacea

Anthony Cacace, Ph.D.

Dr. Cacace is Professor of Audiology, in the Department of Communication Sciences & Disorders at Wayne State University. Prior to this position at Wayne State University, he was full time tenured faculty at Albany Medical College, Albany, NY within the Department of Surgery. At different points in his career, he headed the Audiology Department and Hearing Rehabilitation Center at Albany Medical Center Hospital and was also Director of Oto-neurological Research within the Division of Otolaryngology, Albany Medical College. He then transitioned to the Department of Neurology, and was faculty with the Neurosciences Institute and the Center for Neuroscience Research.
He was awarded a Fellowships with the American Speech-Language Hearing Association (ASHA) in 1997, and the American Academy of Audiology in 1991. He is also a member of the Association for Research in Otolaryngology and The American Audiology Society.

Dr. Cacace is an expert in the areas of psychoacoustics, electroacoustics, electrophysiology, vestibular and balance assessment, repetitive transcranial magnetic stimulation and various magnetic resonance neuroimaging procedures. 
He teaches courses on medical issues, auditory processing disorders, tinnitus, research methods and design. He is also the primary supervisor for Capstone projects withfin the department.

 

Research Interest/Area of Expertise

  •  Psychoacoustics

  •  Electroacoustics

  • Electrophysiology

  •  Vestibular and balance assessment

  •  Repetitive Transcranial Magnetic Stimulation (TMS) & Magnetic Resonance Imaging (MRI)

  •  Tinnitus

  •  Auditory Processing Disorders

Research

Dr. Cacace's current focus includes the study of Central Auditory Processing Disorder, tinnitus, effects of noise on vestibular and balance system and gait related issues.
He is a co-investigator and co-principal investigator on funded research studies through the Veteran’s Administration and the Department of Defense studying the vestibular consequences of blast injuries, blast and concussion-induced tinnitus, and noise induced vestibular dysfunction.

Education – Degrees, Licenses, Certifications

  • BS 1974 Speech Pathology and Audiology, State University of New York
  • MS 1975 Audiology, Syracuse University
  • PhD 1988 Communication Sciences and Disorders/Audiology, Syracuse University
  • PostDoctoral Fellowhip 1987 Neurophysiology, The Wadsworth Center for Laboratories and Research, Central Nervous System Study Section, New York State Health Department

Awards and Grants

  • Current Awards and Grants:

    Veteran’s Administration, Merit Review Award to Avril Genene Holt, Wayne State University, Department of Anatomy and Cell Biology, “Development of Effective Strategies for Tinnitus Diagnosis and Treatment;” Total amount: $1,099,805; October 2013-September, 2017. Anthony T. Cacace, Ph.D., consultant/collaborator.

    National Institutes of Health, R21, Novel Theranostic Approaches to Identify and Treat Tinnitus Using Functionalized Nanoparticles, College of Nanoscale Science and Engineering, University at Albany, Albany, NY, Magnus Berqvist, PI; James Castracane, Co-I, in collaboration with, Anthony T. Cacace, Co-I, Genene Averil Holt, Co-I, Wayne State University (Total cost, WSU $141,805. 00. Start date Nov. 2014, End date Oct 31, 2016, in progress.

    College of Liberal Arts and Sciences, Wayne State University, Omnibus Grant 2015, Department of Communication Sciences & Disorders; Title: Minishaker (Exciter) for oVEMP Elicitation in Evaluating Utricular Function in Humans. Anthony T. Cacace, Ph.D., P.I. $6482.15.
    Department of Veterans Affairs, Rehabilitation Research & Development, Merit Review Award, The Effects of Noise on Vestibular System Function, James H. Quillen VA Medical Center, Faith Wurm Akin (contact) and Averil Genene Holt (Co-PI’s); in collaboration with Anthony T. Cacace, Co-I, Wayne State University; Richard Altschuler and Michael King, Co-I’s, University of Michigan. 4 years, direct costs: $1,481,211.00. Proposed start date April 2016, end date March 2020.

    College of Liberal Arts and Sciences, Wayne State University, Omnibus Grant 2016, Department of Communication Sciences & Disorders; Title: The GaitRite System for Evaluating Gait and Balance Systems in Humans. Anthony T. Cacace, Ph.D., P.I.
    $32,495.00.

Selected Publications

Published Books:

  • Langguth, B., Hajak, G, Kleinjung T, Cacace, A.T., and Møller, A.R. (Editors). Tinnitus: Pathophysiology and Treatment. Progress in Brain Research. Elsevier (2007).
  • Cacace, A.T., and McFarland, D.J. (Editors), Controversies in Central Auditory Processing Disorder. San Diego: Plural Publishing (2009).
  • Cacace, A.T., de Kleine, E., Holt, A. G., van Dijk, P. (Editors), Scientific Foundations of Audiology: Perspectives from physics, biology, modeling, and medicine. San Diego: Plural Publishing (2016).

Published Book Chapters (since 2007):

  • Cacace, A.T., and McFarland, D.J. Frequency domain analysis of event related potentials and oscillations. In: Evoked Potentials: Basic Principles and Clinical Application. In: R.F. Burkard, M. Don, and J.J. Eggermont (eds). Pp. 124-137, Lippincott, Williams, & Wilkins (2007).
  • Cacace, A. T., and Silver, S. M. Applications of magnetic resonance spectroscopy to tinnitus research: Initial data, current issues, and future perspectives. In: B. Langguth, G. Hajak, T. Kleinjung, A.T. Cacace, and A. Møller, editors. Tinnitus: Pathophysiology and Treatment. Progress in Brain Research. Elsevier, 166: 71-81 (2007).
  • B. Langguth, R. Goodey, A. Azevedo, A. Bjorne, A. Cacace et al. Consensus for tinnitus patient assessment and treatment outcome measurement. In: B. Langguth, G. Hajak, T. Kleinjung, A.T. Cacace, and A. Møller, editors. Tinnitus: Pathophysiology and Treatment. Progress in Brain Research. Elsevier, 166: 525-536 (2007).
  • Tyler, R. S., Tao, P., and Cacace, A. T. The neural mechanisms of tinnitus. In: Tyler, R. S. (Editor), The Consumer Handbook of Tinnitus, pp. 31-47. Sedona, AZ: Auricle Ink Publishers (2008).
  • McFarland, D.J., and Cacace, A. T. Modality Specificity and Auditory Processing Disorders, In: Cacace, A. T., and McFarland, D. J. (Editors), Controversies in Central Auditory Processing Disorder. San Diego: Plural (2009).
  • McFarland, D.J., and Cacace, A. T. Towards the Development of Models, Theories, and Test Paradigms in Evaluating and Diagnosing Central Auditory Processing Disorder (CAPD). In: Cacace, A. T., and McFarland, D. J. (Editors), Controversies in Central Auditory Processing Disorder. San Diego: Plural (2009).
  • Cacace, A. T., and Burkard, R.F. Auditory neuropathy: Bridging the gap between basic research and current clinical concerns. In: Cacace, A. T., and McFarland, D. J. (Editors), Controversies in Central Auditory Processing Disorder. San Diego: Plural (2009).
  • Cacace, A.T., and McFarland, D.J. Middle latency auditory evoked potentials: Basic issues and potential applications. In: J. Katz, editor, Handbook of Clinical Audiology, 6th Edition, (2009).
  • May, J., Ramchandran, V., and Cacace, A. T. Tinnitus and vestibular schwannoma: Overview and clinical correlations. In: A. R. Møller, D. DeRidder, B. Languth (Editors). Textbook of Tinnitus, Humana-Springer (2011).
  • Cacace, A. T., and Burkard, R. F. What is auditory neuropathy? Translational studies that distinguish inner hair cell (IHC) from auditory-nerve (AN) dysfunction. In R. Goldfarb (Ed.). Translational Studies in Speech Pathology and Audiology: Essays in Honor of Dr. Sadanand Singh (2012).
  • Cacace, A. T., and McFarland, D. J. Single and double dissociations as a frame-of-reference: Application to auditory processing disorders (APDs). In R. Goldfarb (Ed.). Translational Studies in Speech Pathology and Audiology: Essays in Honor of Dr. Sadanand Singh, pp. 179-184 (2012).
  • McFarland, D. J., and Cacace, A. T. Establishing the construct validity of the auditory processing disorder (APD): Application of psychometric theory to clinical practice. In R. Goldfarb (Ed.). Translational Studies in Speech Pathology and Audiology: Essays in Honor of Dr. Sadanand Singh, 185-191 (2012).
  • Cacace, A.T., and McFarland, D.J. Middle latency auditory evoked potentials. In: J. Katz, editor, Handbook of Clinical Audiology, 7th Edition, (2014) (2014).
  • Tyler, R. S., Tao, P., and Cacace, A. T. The neural mechanisms of tinnitus. In: Tyler, R. S. (Editor), The Consumer Handbook of Tinnitus, pp. 31-47. Sedona, AZ: Auricle Ink Publishers (updated; 2014).
  • Cacace, A. T., and Burkard, R. F. The Audiogram: What it measures, what it predicts, and what it misses. In: Cacace, A. T., de Kleine, E., Holt, A. G., van Dijk, P. (Eds.), Scientific Foundations of Audiology: Perspectives from Physics, Biology, Modeling, and Medicine. San Diego: Plural Publishing, (2016), pp. 57-71.
  • McFarland, D. J., and Cacace, A. T. Theoretical considerations in developing an APD construct: A neuroscience perspective. In: Cacace, A. T., de Kleine, E., Holt, A. G., van Dijk, P. (Eds.), Scientific Foundations of Audiology: Perspectives from Physics, Biology, Modeling Processing Disorder (CAPD)., and Medicine. San Diego, Plural Publishing, (2016), pp. 321-330.
  • Cacace, A. T., Holt, A. G., Bergqvist, M., Castracane, J., Dixon, A., Curley, S., Apawu, A.K. Can we develop a silver “nano-bullet” for tinnitus? Practical and theoretical implications of a nanotheranostic framework. In: Rahman, A. U. (Ed.). Frontiers in Clinical Drug Research-CNS and Neurological Disorders, Bentham Scientific Publishers (In press, 2017).
     

Other Publications (since 2007):

  • Cacace, A. T. and Silver, S. M. Using magnetic resonance spectroscopy to understand the causes of tinnitus. Tinnitus Today, 32: (March) 14-15 (2007).
  • Cacace, A. T. Aging, Alzheimer’s disease, and hearing impairment: Highlighting relevant issues and calling for additional research. Am. J. Audiol. 16: 2-3 (2007).
  • Lee, S. L., Abraham, M., Cacace, A. T., and Silver, S. M. Repetitive transcranial magnetic stimulation in veterans with debilitating tinnitus, a pilot study. Amer. J. Otolaryngol. Head Neck Surg. 138: 398-399 (2008).
  • Romero, S. G., McFarland, D. J., Faust, R., Farrell, L., and Cacace, A. T. Electrophysiological markers of skill-related neuroplasticity. J. Biol. Psychol. 78: 221-230 (2008).
  • Cacace, A.T., and Pinheiro, J.M.B. The mitochondrial connection in auditory neuropathy. Audiol. Neuro-Otol. 16: 398-413 (2011).
  • McFarland, D. J., and Cacace, A. T. Covariance is the proper measure of test-retest reliability. Clin. Neurophysiol. 122:1893 (2011).
  • Lawfield, A., McFarland, D. J., and Cacace, A. T. Dichotic and dichoptic digit perception in normal adults. J. Amer. Acad. Audiol. 22: 332-341 (2011).
  • Carpenter, M. S., Cacace, A. T., and Mahoney, M. J. Missing links in some curious auditory phenomena: a tale from the middle ear. J. Amer Acad. Audiol. 23: 106-114 (2012).
  • Humes, L., Dubno, J., Gordan-Salant, S., Lister, J., Cacace, A.T., Cruickshanks, K., Gates, G., Wilson, R., Wingfield, A. Central presbycusis: A review and evaluation of the evidence. J. Amer Acad. Audiol. 23, 635-666 (2012).
  • Landegrebe, M., Azevedo A, Baguley D, Bauer C, Cacace A. T., Coelho C, et al. Clinical aspects of clinical trials in tinnitus: A proposal for an international standard. J. Psycho. Med. 73, 112-1121 (2012).
  • McFarland, D.J., and Cacace, A. T. Questionable reliability of the speech-evoked auditory brainstem response (sABR) in typically-developing children. Hear. Res. 287, 1-2 (2012).
  • Mahoney, M. J., McFarland, D. J., Carpenter, M. S., Cacace, A. T. Reliability of broadband middle-ear power-reflectance measures in younger and older adults: Application of Generalizability Theory. Amer. J. Audiol. 22, 241-251 (2013).
  • Cacace, A. T., McFarland, D. J. Factors influencing tests of central auditory processing: A perspective on current issues and relevant concerns. J. Amer. Acad. Audiol. 24, 572-589 (2013).
    Benson, R., Gattu, R., Cacace, A. T. Left hemisphere fractional anisotropy increase in noise-induced tinnitus: A diffusion tensor imaging (DTI) study of white matter tracts in the brain. Hear Res. 309, 8-16 (2014).
  • Roberts, L., Cacace, A.T. Jendrassik maneuver facilitates cVEMP amplitude: Some preliminary observations. J. Amer. Acad. Audiol. 25, 237-243 (2014).
  • Cacace, A.T., Brozoski, T., Berkowitz, B., Bauer, C., Castracane, J., Berkvist, M. Zhang, J., Holt, AG. Manganese enhanced MRI: A powerful new imaging method to study tinnitus. Hear Res. 311, 49-62 (2014).
  • Cacace, A. T., McFarland, D. J. Modality specificity trumps other methods for diagnosing the auditory processing disorder (APD): Response to Dillon et al. J Am Acad Audiol. 25, 703-705 (2014).
  • McFarland, D. J., Cacace, A. T. Modality specificity is the preferred method for diagnosing the auditory processing disorder (APD): Response to Moore and Ferguson. J Am Acad Audiol. 25, 698-699 (2014).
  • Cacace, A. T., McFarland, D. J. Lack of a coherent theory limits the diagnosis and prognostic value of the central auditory processing disorder (CAPD). J. Acoust. Soc. Amer. 136, 2258 (2014).
  • Tyler, R. S., Pienkowski, M., Roncancio, E. R., Jun, H. J., Brozoski, T., Dauman, N., Coelho, C. B., Anderrson, G., Keiner, A. J., Cacace, A., Martin, N., Moore, B. C. J. A review of hyperacusis and future directions: Part I. Definition and manifestations. Am. J. Audiol. 23, 402-419 (2014).
  • Pienkowski, M., Tyler, R. S., Roncancio, E. R., Jun, H. J., Brozoski, T., Dauman, N., Coelho, C. B., Anderrson, G., Keiner, A. J., Cacace, A., Martin, N., Moore, B. C. J. A Comprehensive Review of Hyperacusis and Future Directions: Part II. Measurement, Mechanisms, and Treatment. Am. J. Audiol. 23, 420-436 (2014).
  • Gattu, R., Akin, F. W., Cacace, A. T., Murnane, O., Haacke, E. M. Vestibular, balance, microvascular and white matter neuroimaging characteristics of blast injuries and mild traumatic brain injury: Four case reports. Brain Trauma 30, 1501-1514 (2016).
     

 

Currently Teaching

  •  AUD 8350-001   Research Seminar 1

  •  AUD 8350-002   Research Seminar 2

  •  AUD 8350-003   Research Seminar 3

  •  AUD 8440-001   Medical Issues: Tinnitus, Central Auditory Processing 

  • Doctoral Seminar