Matthew J. Allen

Matthew J. Allen

Chair and Professor

313-577-2070

313-577-3585 (fax)

mallen@chem.wayne.edu

Chem 243

Websites

chem.wayne.edu/allengroup

Matthew J. Allen

Research Interest/Area of Expertise

  • Lanthanide chemistry, contrast agents for magnetic resonance imaging, catalysis, molecular imaging, coordination chemistry

Research

Research in the Allen laboratory explores the chemistry of magnetic resonance imaging (MRI) and asymmetric catalysis. We are at the frontier of inorganic chemistry intersecting with organic synthesis, analytical chemistry, and biology. Because of the multidisciplinary approach to science in the laboratory, group members are exposed to a wide variety of synthetic and analytical techniques from chemical and biological disciplines. Specifically, projects in the group require the synthesis of inorganic and organic molecules; characterization of these compounds using a variety of techniques including multinuclear NMR spectroscopy, mass spectrometry, fluorescence spectroscopy, and cyclic voltammetry; and compound testing through catalytic transformations or in vitro and in vivo imaging experiments.

Two major aims in the group are (1) to overcome critical barriers to the advanced use of lanthanide-based contrast agents for MRI and (2) to elucidate mechanistic details of water-tolerant lanthanide-catalyzed organic reactions with the goal of generating improved catalysts.

(1) Magnetic Resonance Imaging: MRI can be used to noninvasively visualize the inside of living organisms. This property of MRI has greatly advanced the ability to diagnose disease and evaluate medical conditions. Lanthanide complexes can enhance inherent contrast in MR images through interactions with solvent molecules. Through the selective enhancement of contrast, MRI can be converted into an even more powerful tool for imaging biological events on the molecular level (molecular imaging); however, there are major limitations to the use of existing rare earth complexes in improving the diagnostic capabilities of MRI and in the study of complicated biological systems. To overcome these limitations, our laboratory uses novel coordination chemistry to manipulate the properties of lanthanide ions. Specifically, we are interested in controlling the magnetic and electronic interactions of lanthanide ions with their surrounding environment and in stabilizing unstable oxidation states. These projects will illuminate fundamental properties of lanthanides. Additionally, they are an inroad toward greatly enhancing the molecular imaging and diagnostic capabilities of MRI.

(2) Asymmetric Catalysis: The use of water-tolerant catalysts is of great consequence in synthesizing organic molecules in a more environmentally benign manner. The Allen laboratory is interested in the study of lanthanide-based, water-tolerant, asymmetric catalysts for organic transformations including aldol, Mannich, and Diels-Alder reactions. Over the last decade, the use of lanthanide triflates as water-tolerant catalysts for organic transformations has been developed; however, mechanistic details of these reactions are largely unknown. During the development of these catalysts, the field of MRI inspired the generation of advanced techniques for characterizing and manipulating the properties of lanthanide ions. Our group is working at the intersection of these two fields to design and study lanthanide triflate-based catalysts with high enantioselectivity and water-stability. By studying and improving lanthanide-based catalysts, we hope to increase the quality and number of more environmentally benign catalysts for the synthesis of organic molecules.

Education – Degrees, Licenses, Certifications

  • B.S., Purdue University, 1998
  • Ph.D., California Institute of Technology, 2004
  • NIH Postdoctoral Fellow, University of Wisconsin-Madison, 2004-2007

Selected Publications

Ekanger, L. A.; Basal, L. A.; Allen, M. J.* The Role of Coordination Environment and pH in Tuning the Oxidation Rate of Europium(II). Chem. Eur. J. 2017, 23, 1145–1150

Tu, Y.-J.; Allen, M. J.; Cisneros, G. A.* Simulations of Water Exchange Dynamics on Lanthanide Ions in 1-Ethyl-3-Methylimidazolim Ethyl Sulfate ([EMIm][EtSO4]) and Water. Phys. Chem. Chem. Phys. 2016, 18, 30323–30333.

White, S. A.; Piechocki, J. A., Jr.; Allen, M. J.* Building an Outstanding ACS Student Chapter. In Building and Maintaining Award-Winning ACS Student Member Chapters Volume 1: Holistic Viewpoints; Mio, M. J., Benvenuto, M. A., Eds.; ACS Symposium Series 1229; American Chemical Society: Washington, DC, 2016; Chapter 1, pp 1–14.

Jin, G.; Bailey, M. D.; Allen, M. J.* Unique Eu(II) Coordination Environments with a Janus Cryptand. Inorg. Chem. 2016, 55, 9085–9090.

Ekanger, L. A.; Mills, D. R.; Ali, M. M.; Polin, L. A.; Shen, Y.; Haacke, E. M.; Allen, M. J.* Spectroscopic Characterization of the +3 and +2 Oxidation States of Europium in a Macrocyclic Tetraglycinate Complex. Inorg. Chem. 2016, 55, 9981–9988.

Currently Teaching

  • CHM 2999  Honors Research Problems in Chemistry, 3 credit hours F2017
    CHM 5998  Honors Thesis Research in Chemistry, 2-4 credits hours F2017
    CHM 5999  Research in Chemistry, 2-4 credit hours F2017
    CHM 6990  Directed Study, 1-4 credit hours F2017
    CHM 6991  Internship in Chemistry, 1 credit hour F2017
    CHM 7990  Directed Study, 1-4 credit hours F2017
    CHM 8700  Research in Chemistry, 1-16 credit hours F2017
    CHM 8820  Seminar in Inorganic Chemistry, 1 credit hour F2017
    CHM 8999  Master's Thesis Research and Direction, 1-8 credits hours F2017
    CHM 9990  Pre-Doctoral Candidacy Research, 1-8 credit hours F2017
    CHM 9991  Doctoral Candidate Status I: Dissertation Research and Direction, 7.5 credit hours F2017
    CHM 9992  Doctoral Candidate Status II: Dissertation Research and Direction, 7.5 credit hours F2017
    CHM 9993  Doctoral Candidate Status III: Dissertation Research and Direction, 7.5 credit hours F2017
    CHM 9994  Doctoral Candidate Status IV: Dissertation Research and Direction, 7.5 credit hours F2017
    CHM 9995  Candidate Maintenance Status: Doctoral Dissertation Research and Direction, 0 credit hour F2017
    CHM 1220  General Chemistry I, 4 credit hours F2017

     

     

     

     

     

     

     

     

     

Courses taught

CHM 2999  Honors Research Problems in Chemistry, 2-4 credit hours S2017
CHM 5998  Honors Thesis Research in Chemistry, 2-4 credit hours S2017
CHM 5999  Research in Chemistry, 2-4 credit hours S2017
CHM 6990  Directed Study, 1-4 credit hours S2017
CHM 6991  Internship in Chemistry, 1 credit hour S2017
CHM 7990  Directed Study, 1-4 credit hours S2017
CHM 8700  Research in Chemistry, 1-16 credit hours S2017
CHM 8999  Master's Thesis Research and Direction, 1-8 credits hours S2017
CHM 9991  Doctoral Candidate Status I: Dissertation Research and Direction, 7.5 credit hours S2017
CHM 9992  Doctoral Candidate Status II: Dissertation Research and Direction, 7.5 credit hours S2017
CHM 9993  Doctoral Candidate Status III: Dissertation Research and Direction, 7.5 credit hours S2017
CHM 9994  Doctoral Candidate Status IV: Dissertation Research and Direction, 7.5 credit hours S2017
CHM 9995  Candidate Maintenance Status: Doctoral Dissertation Research and Direction, 0 credit hour S2017