Research Interest/Area of Expertise
Organic synthesis, inorganic synthesis, metal-based drug design, catalysis, iron chemistry, ligand design and coordination chemistry.
Research in the Kodanko laboratory is at the interface of organic, inorganic and medicinal chemistry. We are interested in harnessing the power of metal complexes for biological applications. Projects currently being conducted in the Kodanko laboratory span across many subdisciplines of chemistry research including organic and inorganic synthesis, catalysis, kinetic and mechanistic studies, coordination chemistry, enzyme inhibition and cell biology. Recent interests have focused on the development of light-activated compounds for biological research applications, and as potential therapeutics.
Education – Degrees, Licenses, Certifications
- B.S., University of Wisconsin-Madison, 1998
- Ph.D., University of California-Irvine, 2003
- NIH Postdoctoral Fellow, Massachusetts Institute of Technology, 2003-6
Awards and Grants
National Science Foundation
Design of New Ru(II) Complexes to Control Excited State Reactivity
Role: Co-PI (with PI Turro and Co-PI Dunbar)
Period of Support: 08/01/2018-07/31/2021
Award: National Institutes of Health
Grant Number: 5R01EB016072
Light Activation of Enzyme Inhibition
Co-investigators: Claudia Turro, Izabela Podgorski
Period of Support: 4/15/2013-3/31/2018
Award: Penrose Therapeutx
Grant Number: 25S2E
Elucidating Mode of Action for Detastanib, A Novel Combination Therapy for Cancer
Period of Support: 11/01/2016-08/31/2018
Award: Michigan Corporate Relations Network
Grant Number: 25S2F
Elucidating Mode of Action for Detastanib, A Novel Combination Therapy for Cancer (Matching Funds)
Period of Support: 1/01/2017-12/31/2017
Remote Functionalization Reactions Catalyzed by Multinuclear Complexes
Award: American Chemical Society Petroleum Research Fund Type G
Grant Number: 46714-G1
Period of Support: 9/1/2007-8/31/2009
Li, A.; White, J. K.; Arora, K.; Herroon, M. K.; Martin, P. D.; Schlegel, H. B.; Podgorski, I.; Turro, C.; Kodanko, J. J. "Selective Release of Aromatic Heterocycles from Ruthenium Tris(2-pyridylmethyl)amine with Visible Light" Inorg. Chem. 2016, 55, 10.
Ramalho, S. D.; Sharma, R.; White, J. K.; Aggarwal, N.; Chalasani, A.; Sameni, M.; Moin, K.; Vieira, P. C.; Turro, C.; Kodanko, J. J.; Sloane, B. F. "Imaging sites of inhibition of proteolysis in pathomimetic human breast cancer cultures by light-activated ruthenium compound" PLoS One 2015, 10, e0142527/1.
Sharma, R.; Knoll, J. D.; Ancona, N.; Martin, P. D.; Turro, C.; Kodanko, J. J. "Solid-Phase Synthesis as a Platform for the Discovery of New Ruthenium Complexes for Efficient Release of Photocaged Ligands with Visible Light" Inorg. Chem. 2015, 54, 1901.
Respondek, T.; Sharma, R.; Herroon, M. K.; Garner, R. N.; Knoll, J. D.; Cueny, E.; Turro, C.; Podgorski, I.; Kodanko, J. J. "Inhibition of Cathepsin Activity in a Cell-Based Assay by a Light-Activated Ruthenium Compound" ChemMedChem 2014, 9, 1306.
Respondek, T.; Garner, R. N.; Herroon, M. K.; Podgorski, I.; Turro, C.; Kodanko, J. J. "Light Activation of a Cysteine Protease Inhibitor: Caging of a Peptidomimetic Nitrile with RuII(bpy)2" J. Am. Chem. Soc. 2011, 133, 17164.
CHM 6240/7240 Organic Spectroscopy, 3 credit hours F2016, W2017, W2018
CHM 7740 Responsible Conduct of Research, 1 credit hours F2016