Jeremy Kodanko

Jeremy Kodanko

Associate Chair
Associate Professor

313-577-9043

313-577-8822 (fax)

jkodanko@chem.wayne.edu

Chem 261

Websites

chem.wayne.edu/kodankogroup

Jeremy Kodanko

Research Interest/Area of Expertise

  • Organic synthesis, inorganic synthesis, metal-based drug design, catalysis, iron chemistry, ligand design and coordination chemistry.

Research

 

Research in the Kodanko laboratory is at the interface of organic, inorganic and medicinal chemistry. We are interested in harnessing the power of metal complexes for biological applications. Projects currently being conducted in the Kodanko laboratory span across many subdisciplines of chemistry research including organic and inorganic synthesis, catalysis, kinetic and mechanistic studies, coordination chemistry, enzyme inhibition and cell biology. Recent interests have focused on the development of light-activated compounds for biological research applications, and as potential therapeutics.

 

 

Education – Degrees, Licenses, Certifications

  • B.S., University of Wisconsin-Madison, 1998
  • Ph.D., University of California-Irvine, 2003
  • NIH Postdoctoral Fellow, Massachusetts Institute of Technology, 2003-6

Awards and Grants

  •  National Science Foundation
    Design of New Ru(II) Complexes to Control Excited State Reactivity
    Role: Co-PI (with PI Turro and Co-PI Dunbar)
    Period of Support: 08/01/2018-07/31/2021

    Award: National Institutes of Health
    Grant Number: 5R01EB016072
    Light Activation of Enzyme Inhibition
    Role: PI
    Co-investigators: Claudia Turro, Izabela Podgorski
    Period of Support: 4/15/2013-3/31/2018

    Award: Penrose Therapeutx
    Grant Number: 25S2E
    Elucidating Mode of Action for Detastanib, A Novel Combination Therapy for Cancer
    Role: PI
    Period of Support: 11/01/2016-08/31/2018

    Award: Michigan Corporate Relations Network
    Grant Number: 25S2F
    Elucidating Mode of Action for Detastanib, A Novel Combination Therapy for Cancer (Matching Funds)
    Role: PI
    Period of Support: 1/01/2017-12/31/2017

    Remote Functionalization Reactions Catalyzed by Multinuclear Complexes
    Role: PI
    Award: American Chemical Society Petroleum Research Fund Type G
    Grant Number: 46714-G1
    Period of Support: 9/1/2007-8/31/2009

     

     

Selected Publications

Li, A.; White, J. K.; Arora, K.; Herroon, M. K.; Martin, P. D.; Schlegel, H. B.; Podgorski, I.; Turro, C.; Kodanko, J. J. "Selective Release of Aromatic Heterocycles from Ruthenium Tris(2-pyridylmethyl)amine with Visible Light" Inorg. Chem. 2016, 55, 10.

Ramalho, S. D.; Sharma, R.; White, J. K.; Aggarwal, N.; Chalasani, A.; Sameni, M.; Moin, K.; Vieira, P. C.; Turro, C.; Kodanko, J. J.; Sloane, B. F. "Imaging sites of inhibition of proteolysis in pathomimetic human breast cancer cultures by light-activated ruthenium compound" PLoS One 201510, e0142527/1.

Sharma, R.; Knoll, J. D.; Ancona, N.; Martin, P. D.; Turro, C.; Kodanko, J. J. "Solid-Phase Synthesis as a Platform for the Discovery of New Ruthenium Complexes for Efficient Release of Photocaged Ligands with Visible Light" Inorg. Chem. 201554, 1901.

Respondek, T.; Sharma, R.; Herroon, M. K.; Garner, R. N.; Knoll, J. D.; Cueny, E.; Turro, C.; Podgorski, I.; Kodanko, J. J. "Inhibition of Cathepsin Activity in a Cell-Based Assay by a Light-Activated Ruthenium Compound" ChemMedChem 20149, 1306.

Respondek, T.; Garner, R. N.; Herroon, M. K.; Podgorski, I.; Turro, C.; Kodanko, J. J. "Light Activation of a Cysteine Protease Inhibitor: Caging of a Peptidomimetic Nitrile with RuII(bpy)2" J. Am. Chem. Soc. 2011133, 17164.

 

Courses taught

CHM 6240/7240   Organic Spectroscopy, 3 credit hours   F2016, W2017, W2018
CHM 7740   Responsible Conduct of Research, 1 credit hours   F2016