Jeremy Kodanko
Associate Chair
Professor
313-577-9043
313-577-8822 (fax)
Chem 261
Website(s)
Jeremy Kodanko
Research interest(s)/area of expertise
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Organic synthesis
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Inorganic synthesis
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Metal-based drug design
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Catalysis
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Iron chemistry
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Ligand design
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Coordination chemistry
Research
Research in the Kodanko laboratory is at the interface of organic, inorganic and medicinal chemistry. We are interested in harnessing the power of metal complexes for biological applications. Projects currently being conducted in the Kodanko laboratory span across many subdisciplines of chemistry research including organic and inorganic synthesis, catalysis, kinetic and mechanistic studies, coordination chemistry, enzyme inhibition and cell biology. Recent interests have focused on the development of light-activated compounds for biological research applications and as potential therapeutics.
Education
- B.S., University of Wisconsin-Madison, 1998
- Ph.D., University of California-Irvine, 2003
- NIH Postdoctoral Fellow, Massachusetts Institute of Technology, 2003-6
Awards and grants
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National Science Foundation
Design of New Ru(II) Complexes to Control Excited State Reactivity
Role: Co-PI (with PI Turro and Co-PI Dunbar)
Period of support: 08/01/2018-07/31/2021 -
Award: National Institutes of Health
Grant number: 5R01EB016072
Light Activation of Enzyme Inhibition
Role: PI
Co-investigators: Claudia Turro, Izabela Podgorski
Period of support: 4/15/2013-3/31/2018 -
Award: Penrose Therapeutx
Grant number: 25S2E
Elucidating Mode of Action for Detastanib, A Novel Combination Therapy for Cancer
Role: PI
Period of support: 11/01/2016-08/31/2018 -
Award: Michigan Corporate Relations Network
Grant number: 25S2F
Elucidating Mode of Action for Detastanib, A Novel Combination Therapy for Cancer (Matching Funds)
Role: PI
Period of support: 1/01/2017-12/31/2017 -
Remote Functionalization Reactions Catalyzed by Multinuclear Complexes
Role: PI
Award: American Chemical Society Petroleum Research Fund Type G
Grant number: 46714-G1
Period of support: 9/1/2007-8/31/2009
Selected publications
- Li, A.; White, J. K.; Arora, K.; Herroon, M. K.; Martin, P. D.; Schlegel, H. B.; Podgorski, I.; Turro, C.; Kodanko, J. J. "Selective Release of Aromatic Heterocycles from Ruthenium Tris(2-pyridylmethyl)amine with Visible Light" Inorg. Chem. 2016, 55, 10
- Ramalho, S. D.; Sharma, R.; White, J. K.; Aggarwal, N.; Chalasani, A.; Sameni, M.; Moin, K.; Vieira, P. C.; Turro, C.; Kodanko, J. J.; Sloane, B. F. "Imaging sites of inhibition of proteolysis in pathomimetic human breast cancer cultures by light-activated ruthenium compound" PLoS One 2015, 10, e0142527/1
- Sharma, R.; Knoll, J. D.; Ancona, N.; Martin, P. D.; Turro, C.; Kodanko, J. J. "Solid-Phase Synthesis as a Platform for the Discovery of New Ruthenium Complexes for Efficient Release of Photocaged Ligands with Visible Light" Inorg. Chem. 2015, 54, 1901
- Respondek, T.; Sharma, R.; Herroon, M. K.; Garner, R. N.; Knoll, J. D.; Cueny, E.; Turro, C.; Podgorski, I.; Kodanko, J. J. "Inhibition of Cathepsin Activity in a Cell-Based Assay by a Light-Activated Ruthenium Compound" ChemMedChem 2014, 9, 1306
- Respondek, T.; Garner, R. N.; Herroon, M. K.; Podgorski, I.; Turro, C.; Kodanko, J. J. "Light Activation of a Cysteine Protease Inhibitor: Caging of a Peptidomimetic Nitrile with RuII(bpy)2" J. Am. Chem. Soc. 2011, 133, 17164