# Yu-Chung Cheng

Associate Professor of Radiology

Adjunct to Physics, Adjunct to Biomedical Engineering, and Adjunct to Medical Physics

313-966-8220

Detroit Receiving Hospital

Room 5E-11

# Yu-Chung Cheng

## Department

Radiology

## Research interest(s)/area of expertise

- Physics in Magnetic Resonance Imaging (MRI)
- Susceptibility quantification using MRI
- Iron quantification for early detections of neurodegenarate diseases from MRI
- Magnet designs in MRI
- Thermal ablations
- Handheld sensors for detecting ferric iron
- Astrophysics/cosmology (gravitational lensing) --- past interest

## Research

MRI

## Education

Ph.D.## Awards and grants

- 1. NIH/NHLBI R21 HL108230-01A2, Title: Determining Properties of Subvoxel Objects from MRI Images, Role: Principal investigator, 07/01/10 to 04/30/12, (no cost extension to 04/30/13).
- 2. DOD/USAMRAA W81XWH-12-1-0522, Title: Development and Testing of Iron Based Phantoms as Standards for the Diagnosis of Microbleeds and Oxygen Saturation with Applications in Dementia, Stroke and Traumatic Brain Injury, Role: Principle investigator, 09/30/12 to 09/29/16 (and no-cost extended to 09/29/17), (This work is highlighted by CDMRP at http://cdmrp.army.mil/dmrdp/research_highlights/16cheng_highlight.shtml)
- 3. WSU President’s Research Enhancement Award, Title: Quantifying absolute magnetic moments and susceptibilities of tissues and microbleeds as accurate MRI biomarkers for diagnosing dementia at an early stage, Role: Principle investigator, 10/01/15 to 12/21/17.
- 4. Burroughs Wellcome Fund, Collaborative Research Travel Grant, Title: A Simple Handheld Electrical Device for Early Detection of Malaria, Role: Principle investigator, 07/01/17 to 12/31/18.
- 5. Michigan Alzheimer’s Disease Center, Title: Magnetic properties of microvascular lesions as potential biomarkers for dementia, Role: Principle investigator, 03/01/21 to 02/28/22.
- 6. NIH/NIA 1R21AG069477-01A1, Title: Magnetic susceptibility and volume of microvascular lesions as proof-of-concept biomarkers for mixed dementia, Role: Principle investigator, 05/01/21 to 04/30/23.

## Selected publications

**Patents**

- R. W. Brown, Y.-C. N. Cheng, W. C. Condit, and D. Scheule, Detection of wear-particles and other impurities in industrial or other fluids, US Patent, 6,255,954, July 3, 2001 (role: co-inventor).
- Y.-C. N. Cheng, C.-Y. Hsieh, and E. M. Haacke, Method of and software application for quantifying objects in magnetic resonance images via multiple complex summations, US patent, 7,692,424 B2, April 6, 2010 (role: primary inventor).
- E. M. Haacke, J. Neelavalli, and Y.-C. N. Cheng, Geometry based field prediction method for susceptibility mapping and phase artifact removal, US patent, 7,782,051, August 24, 2010 (role: co-inventor).

**Peer reviewed articles:**

1. Y.-C. N. Cheng, R. W. Brown, Y.-C. Chung, J. L. Duerk, H. Fujita, J. S. Lewin, D. E. Schuele, and S. Shvartsman, Calculated rf electric field and temperature distributions in rf thermal ablation: comparison with gel experiments and liver imaging, Journal of Magnetic Resonance Imaging, vol. 8, no. 1, pp. 70-76, 1998.

2. Y.-C. N. Cheng and L. M. Krauss, Gravitational lensing and dark structures, Astrophysical Journal, vol. 514, pp. 25-32, 1999.

3. Y.-C. N. Cheng and L. M. Krauss, Gravitational lensing statistics and constraints on the cosmological constant revisited, International Journal of Modern Physics A, vol. 15, no. 5, pp. 697-723, 2000.

4. R. W. Brown, Y.-C. N. Cheng, and M. Kurtay, A formula for surgical modifications of the breast, Plastic and Reconstructive Surgery, vol. 106, no. 6, pp. 1342-1345, 2000.

5. S. M. Shvartsman, R. W. Brown, Y.-C. N. Cheng, T. P. Eagan, H. Fujita, M. A. Morich, L. S. Petropoulos, and J. D. Willig, Application of the SUSHI method to the design of gradient coils, Magnetic Resonance in Medicine, vol. 45, no. 1, pp. 147-155, 2001.

6. Y.-C. N. Cheng and L. M. Krauss, An elliptical galaxy luminosity function and velocity dispersion sample of relevance for gravitational lensing statistics, New Astronomy, vol. 6, no. 4, pp. 249-263, 2001.

7. Sh. M. Shvartsman, R. W. Brown, Y.-C. N. Cheng, T. P. Eagan, and J. D. Willig, Supershielding: trapping of magnetic fields, IEEE Transactions on Magnetics, vol. 37, no. 5, pp. 3116 -3119, 2001.

8. Y.-C. N. Cheng, E. M. Haacke, and Y.-J. Yu, An exact form for the magnetic field density of states for a dipole, Magnetic Resonance Imaging, vol. 19, no. 7, pp. 1017-1023, 2001.

9. Y.-C. N. Cheng and E. M. Haacke, Predicting BOLD signal changes as a function of blood volume fraction and resolution, NMR in Biomedicine, vol. 14, no. 7-8, pp. 468-477, 2001.

10. R. W. Brown, Y.-C. N. Cheng, T. P. Eagan, T. K. Kidane, H. Mathur, R. G. Petschek, W. G. Sherwin, Sh. M. Shvartsman, and J. D. Willig, Toward improvements in MRI shielding, Magnetic Resonance Materials in Biology, Physics, and Medicine, vol. 13, no. 3, pp. 186-192, 2002.

11. Y.-C. N. Cheng, T. P. Eagan, T. Chmielewski, J. Folck, M.-C. Kang, T. K. Kidane, Sh. M. Shvartsman, and R. W. Brown, A degeneracy study in the circulant and bordered-circulant approach to birdcage and planar coils, Magnetic Resonance Materials in Biology, Physics, and Medicine, vol. 16, no. 2, pp. 103-111, 2003.

12. Y.-C. N. Cheng, T. P. Eagan, R. W. Brown, Sh. M. Shvartsman, and M. R. Thompson, Design of actively shielded main magnets: an improved functional method, Magnetic Resonance Materials in Biology, Physics, and Medicine, vol. 16, no. 2, pp. 57-67, 2003.

13. E. M. Haacke, Y. Xu, Y.-C. N. Cheng, and J. Reichenbach, Susceptibility weighted imaging, Magnetic Resonance in Medicine, vol. 52, no. 3, pp. 612-618, 2004.

14. Y.-C. N. Cheng, R. W. Brown, M. R. Thompson, T. P. Eagan, and Sh. M. Shvartsman, A comparison of two design methods for MRI magnets, IEEE Transactions on Applied Superconductivity, vol. 14, no. 3, pp. 2008-2014, 2004.

15. T. P. Eagan, Y.-C. N. Cheng, T. K. Kidane, H. Mathur, T. Chmielewski, J. Folck, Sh. M. Shvartsman, and R. W. Brown, A group theory approach to rf coil design, Concepts in Magnetic Resonance Part B: Magnetic Resonance Engineering, vol. 25B, no. 1, pp. 42-52, 2005.

16. W. A. Edelstein, T. K. Kidane, V. Taracila, T. N. Baig, T. P. Eagan, Y.-C. N. Cheng, R. W. Brown, and J. A. Mallick, Active-passive gradient shielding for MRI acoustic noise reduction, Magnetic Resonance in Medicine, vol. 53, no. 5, pp. 1013-1017, 2005.

17. T. K. Kidane, W. A. Edelstein, T. P. Eagan, V. Taracila, T. N. Baig, Y.-C. N. Cheng, and R. W. Brown, Active-passive shielding for MRI acoustic noise reduction: network analysis, IEEE Transactions on Magnetics, vol. 42, no. 12, pp. 3854-3860, 2006.

18. Y.-C. N. Cheng, C.-Y. Hsieh, J. Neelavalli, Q. Liu, M. S. Dawood, and E. M. Haacke, A complex sum method of quantifying susceptibilities in cylindrical objects: The first step toward quantitative diagnosis of small objects in MRI, Magnetic Resonance Imaging, vol. 25, no. 8, pp. 1171-1180, 2007.

19. K. S. Parthasarathy, Y.-C. N. Cheng^, J. P. McAllister II, Y. Shen, J. Li, K. Deren, E. M. Haacke, and G. W. Auner, Biocompatibilities of sapphire and borosilicate glass as cortical neuroprostheses, Magnetic Resonance Imaging, vol. 25, no. 9, pp. 1333-1340, 2007 (^ corresponding author).

20. Y. Shen, Y.-C. N. Cheng^, G. Lawes, J. Neelavalli, C. Sudakar, R. Tackett, H. P. Ramnath, and E. M. Haacke, Quantifying magnetic nanoparticles in non-steady flow by MRI, Magnetic Resonance Materials in Biology, Physics, and Medicine, vol. 21, no. 5, pp. 345-356, 2008 (^ corresponding author).

21. J. Neelavalli*, Y.-C. N. Cheng, J. Jiang, and E. M. Haacke, Removing background phase variations in susceptibility weighted imaging using a fast, forward-field calculation, Journal of Magnetic Resonance Imaging, vol. 29, pp. 937-948, 2009.

22. Y.-C. N. Cheng, J. Neelavalli, and E. M. Haacke, Limitations of calculating field distributions and magnetic susceptibilities in MRI using a Fourier based method, Physics in Medicine and Biology, vol. 54, pp. 1169-1189, 2009. (This paper has been considered as one of the ten best papers in this journal in 2009. See Editorial of vol. 55, Number 14, 2010, doi: 10.1088/0031-9155/55/14/E01.)

23. Y.-C. N. Cheng, C.-Y. Hsieh, J. Neelavalli, and E. M. Haacke, Quantifying effective magnetic moments of narrow cylindrical objects in MRI, Physics in Medicine and Biology, vol. 54, pp. 7025-7044, 2009.

24. E. M. Haacke, J. Tang, J. Neelavalli, and Y.-C. N. Cheng, Susceptibility mapping as a means to visualize veins and quantify oxygen saturation, Journal of Magnetic Resonance Imaging, vol. 32, pp. 663-676, 2010.

25. S. Liu, J. Neelavalli, Y.-C. N. Cheng, J. Tang, and E. M. Haacke, Quantitative susceptibility mapping of small objects using volume constraints, Magnetic Resonance in Medicine, vol. 69, no. 3, pp. 716-723, 2013.

26. J. Tang, S. Liu, J. Neelavalli, Y.-C. N. Cheng, S. Buch, and E. M. Haacke, Improving susceptibility mapping using a threshold-based k-space/image domain iterative reconstruction approach, Magnetic Resonance in Medicine, vol. 69, no. 5, pp. 1396-1407, 2013.

27. W. Zheng, H. Nichol, S. Liu, Y.-C. N. Cheng, and E. M. Haacke, Measuring iron in the brain using quantitative susceptibility mapping and X-ray fluorescence imaging, NeuroImage, vol. 78, pp. 68-74, 2013.

28. Y.-M. Shen, W.-L. Zheng, Y.-C. N. Cheng, Y.-C. Ding, T. Higashida, J. Li, Y.-Q. Ye, J.-S. Raynaud, and E. M. Haacke, USPIO high resolution neurovascular imaging in a rat stroke model of transient middle cerebral artery occlusion, Chinese Journal of Magnetic Resonance, vol. 31, no. 1, pp. 20-31, 2014.

29. S. Liu, K. Mok, J. Neelavalli, Y.-C. N. Cheng, J. Tang, Y. Ye, and E. M. Haacke, Improved MR venography using quantitative susceptibility-weighted imaging, Journal of Magnetic Resonance Imaging, vol. 40, no. 3, pp. 698-708, 2014.

30. C.-Y. Hsieh, Y.-C. N. Cheng^, J. Neelavalli, E. M. Haacke, and R. J. Stafford, An improved method for susceptibility and radius quantification of cylindrical objects from MRI, Magnetic Resonance Imaging, vol. 33, no. 4, pp. 420-436, 2015 (^ corresponding author).

31. S. Buch, S. Liu, Y. Ye, Y.-C. N. Cheng, J. Neelavalli, and E. M. Haacke, Susceptibility mapping of air, bone, and calcium in the head, Magnetic Resonance in Medicine, vol. 73, no. 6, pp. 2185-2194, 2015.

32. Y.-C. N. Cheng, C.-Y. Hsieh, R. Tackett, P. Kokeny, R. K. Regmi, and G. Lawes, Magnetic moment quantifications of small spherical objects in MRI, Magnetic Resonance Imaging, vol. 33, no. 6, pp. 829-839, 2015.

33. C.-Y. Hsieh, Y.-C. N. Cheng^, H. Xie, E. M. Haacke, and J. Neelavalli, Susceptibility and size quantification of small human veins from an MRI method, Magnetic Resonance Imaging, vol. 33, no. 10, pp. 1191-1204, 2015 (^ corresponding author).

34. H. Xie, Y.-C. N. Cheng^, P. Kokeny, S. Liu, C.-Y. Hsieh, E. M. Haacke, M. P. Arachchige, and G. Lawes, A quantitative study of susceptibility and additional frequency shift of three common materials in MRI, Magnetic Resonance in Medicine, vol. 76, no. 4, pp. 1263-1269, 2016 (^ corresponding author).

35. P. Kokeny, Y.-C. N. Cheng^, S. Liu, H. Xie, and Q. Jiang, Quantifications of in vivo labeled stem cells based on measurements of magnetic moments, Magnetic Resonance Imaging, vol. 35, pp. 141-147, 2017 (^ corresponding author).

36. S. Buch, Y.-C. N. Cheng, J. Hu, S. Liu, J. Beaver, R. Rajagovindan, and E. M. Haacke, Determination of detection sensitivity for cerebral microbleeds using susceptibility-weighted imaging, NMR in Biomedicine, vol. 30, no. 4, p. e3551, 2017.

37. P. Kokeny, Y.-C. N. Cheng^, and H. Xie, A study of MRI gradient echo signals from discrete magnetic particles with considerations of several parameters in simulations, Magnetic Resonance Imaging, vol. 48, pp. 129-137, 2018. (^ corresponding author)

38. H. Xie*, Y.-C. N. Cheng^, S. Liu*, and P. Kokeny*, Removing unwanted background phase with a reference phantom for applications in susceptibility quantification, Magnetic Resonance Imaging, vol. 54, pp. 32-45, 2018. (^ corresponding author)

39. P. Kokeny*, Y.-C. N. Cheng^, and H. Xie*, Distributions of discrete spherical particles with a constant susceptibility can lead to echo time dependent phase shifts which deviate from theories, Magnetic Resonance Imaging, vol. 61, pp. 196-206, 2019. (^ corresponding author)

40. Y.-C. N. Cheng, Comments on “Larmor frequency in heterogeneous media”, Journal of Magnetic Resonance, vol. 308, p. 106555, 2019.

**Review articles:**

1. E. M. Haacke, Y.-C. N. Cheng, M. J. House, Q. Liu, J. Neelavalli, R. J. Ogg, A. Khan, M. Ayaz, W. Kirsch, and A. Obenaus, Imaging iron stores in the brain using magnetic resonance imaging, Magnetic Resonance Imaging, vol. 23, no. 1, pp. 1-25, 2005.

2. E. M. Haacke, S. Mittal, Z. Wu, J. Neelavalli, Y.-C. N. Cheng, Susceptibility weighted imaging: Technical aspects and clinical applications, American Journal of Neuroradiology, vol. 30, pp. 19-30, 2009.

**MRI Textbook:**

R. W. Brown, Y.-C. N. Cheng, E. M. Haacke, M. R. Thompson, and R. Venkatesan, Magnetic Resonance Imaging: Physical Principles and Sequence Design, 2nd Edition, Wiley-Blackwell, Hoboken, New Jersey, 2014.

**Edited book (Current Protocols in MRI)**

E. M. Haacke, W. Lin, Y.-C. N. Cheng, C. P. Ho, W. A. Kaiser, J. S. Lewin, Z.-P. Liang, S. K. Mukherji, R. C. Semelka, K. R. Thulborn, and P. K. Woodard, eds, Current Protocols in Magnetic Resonance Imaging, John Wiley & Sons, New York, 2001-2008.

## Courses taught

BME 7710 --- MRI