Bashar Ksebati

Bashar Ksebati

Sr. Research scientist
Manager, NMR Laboratory


(313) 577-1377 (fax)

 wayne state UniversityDepartment of ChemistryRomm 435101 Cass Avedetroit MI, 48202

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Bashar Ksebati

Research Interest/Area of Expertise

  •  Research interests on the chemistry of marine organisms and plants. Structure elucidation by 1D, 2D,  and 3D NMR spectroscopy of biologically active natural product compounds from marine organisms and plants as well as characterization of organic compounds from synthetic pathways.   

Education – Degrees, Licenses, Certifications

  • University of Damascus, Damascus, Syria Chemistry B. S. 1977 University of Oklahoma Chemistry Ph.D. 1984

Awards and Grants

  •  Wayne StateUniversityCollege of Science Presidential Bounce Service Award, 1998




Selected Publications

Research Publications


1.         M. B. Ksebati, L. S. Ciereszko and F. J. Schmitz,"11b, 12b-epoxypukalide,A            Furanocembranoide from the Gorgonian Leptogorgia setacea," J. Nat, prod.,1984,                     47,1009.

2.         M. B. Ksebati and F. J. Schmitz, "24e-methyl-5a-cholestane-3b,5,6b,22R,24-pentanol 6-     Acetate: New polyhydroxylated sterol from the Soft Coral Asterospicularia randalli," Steroids,       1984,43,639.

3.         M. B. Ksebati and F.J. Schmitz, "Tridachiapyrones: Propionate-Derived Metabolites from     the Sacoglossan Mollusc Tridachia Crispata, " J. Org.Chem., 1985,50,5637.

4.         M. B. Ksebati and F. J. Schmitz, "Diterpenes from a Soft  from Truk Lagoon, " Bull Soc.      Chim.   Belg., 1986,95, 835.

5.         L. V. Manes, P. Crews, M. B. Ksebati and F. J. Schmitz, " The Use of Two Dimensional       NMR    and Relaxation Reagents to Determine Sterochemical Features in Acyclic Sesterpenes, " J.           Nat. Prod., 1986, 49, 787.

6.         M. B. Ksebati and F. J. Schmitz, "Nine New Spongiane Diterpenes from an Australian          Nudibranch," J. Org. Chem.,1987, 52, 3766.

7.         M. B. Ksebati, F. J. Schmitz, S. P. Gunasekera, and S. Agarwal, "Sarasinoside A1: A             Saponin             Containing Amino Sugars Isolated from a sponge," J. Org. Chem.,1988, 53, 5941.

8.         M. B. Ksebati, F. J. Schmitz, and S. P. Gunasekera, "Pouosides A-E, Novel Triterpene          Galactosides from a Marine Sponge, Asteropus sp." J. Org. Chem., 1988, 53, 3917.

9.         M. B. Ksebati, and F. J. Schmitz, "Minabeolides, A Group of  Withanolids from a soft          Coral,   Minabea Sp." J. Org. Chem., 1988, 53, 3926.

10.       M. B. Ksebati, and F. J. Schmitz, "Sesquiterpene Furans and Thiosesqui-terpenes from         the       Nudibranch Ceratosoma  brevicaudatum." J. Nat. Prod., 1988, 51, 857.                             

11.       M. B. Ksebati, F. J. Schmitz, J. S. Chang, M. B. Hossain, D. van derHelm, M. H. Engel,        and A. Serban. "Cyclic Peptides from the Ascidian Lissoclinum Patella; Conformational       analysis of       Patellamide D by X-ray analysis and Molecular Modeling." J. Org. Chem.,      1989, 54, 3463.


12.       M. B. Ksebati, F. J. Schmitz, G. K Liyanage, W. D. Ratnasooriya, and L. M V.          Tillekeratne. "A             New  Spermatostatic Glycoside from the Soft Coral Sinularia Crispa." J.        Nat. Prod., 1989, 52, 1143.

13.       M. B. Ksebati, K. Stone, and L. J. Marnett, "Investigation of the Adducts Formed by             Reaction of Malondialdehyde with adenosine." Chem. Res.Toxicol. 1990, 3, 33.

14.       M. B. Ksebati, R. J. Hood, C. A. Schwartz, G. G. Konduri, and Y. W. Brans.," Deuterium     Enrichment of plasma  Determined by Nuclear Magnetic Resonance Spectroscopy: Dilution           Clinical Chemistry, 1990 ,36, 1823.

15.       M. B. Ksebati, Ana M. Q. Vande Linde, Kerri L. Juntunen, Ole .Mols, L. A.  Ochrymoycz,   And D. B. Rorabacher "Direct Determination of the Self-Exchange Electron-Transfer Rate        Constant for a Copper(II/I) Macrocyclic Pentathiaether Complex". Inorganic        Chemistry,1991,          30, 5037.

16.       M. B. Ksebati, Ching Y. Wang, Hisamitsu Nagase, and Mei-sie Lee, "  Arylamination and     Arylation of 4,4,4-Trifluoro-1-phenyl-1,3-butanedione with N-Acetoxy Derivatives of 2-          Aminofluorene," Chem . Res. Toxicol. 1992, 5, 183.

17.       M. B. Ksebati, R. V. Joshi, Ze Qi Xu, D. Kessel, T. H.  Corbertt, J.  C. Drach, and J.             Zemlicka, "Synthesis, Transformations and Biological Activity of Chloroenamines and             Ynamines comprising Purine and Pyrimidine Ring Systems of Nucleic Acids . "  J, Chem,         Soc, Perkin; Trans.,1994 ; 1; 1089..

18.       M B. Ksebati, Carl .R. Johnson ,Michael. M. Miller, Adam. Golebiowski, and Hari.   Sundram. "Synthesis of Aza-C-disaccharides - a New Class of Sugar Mimics".            Tetrahedron     Lett. 1994, 35, 8991.


19.       M. B. Ksebati, E. Palomino, M. B. Kempff, and C. Maldondo. " Caparratriene, An Active     Sesquiterpene Hydrocarbon from Ocotea Caparrari (Nates) Dugand."  J. Nat. Prod.,            1996, 59, 77.

20.       M. B. Ksebati, Y. Qiu, R. G. Ptak, B. Y. Fan, J. M. Breitenbach, J. Lin, Y. Cheng, E. R.        Kern, J.            C. Drach, and J. Zemlicka, "(Z)- and (E)-2-         (Hydroxymethylcyclopropylidene)methyladenine       and -guanine -New Nucleoside       Analogues with a Broad-spectrum Antiviral Activity."  J. Med.           Chem.1998, 41,10-23.

21.       M. B. Ksebati, T. J. Zahn, and R. A. Gibbs, " Sysnthesis and Conformational Analysis of     DI-13C-            labeled Farnesyl Diphosphate Analogs. " Tetrahedron Letters., 1998, 39, 3991.

22.       M. B. Ksebati, J. Li, W. Zhang, Z. Guo, J. Wang ,L. Yu, J. Fang, and P. G. Wang, "   Conformational Analysis of An a-Galactosyl Trisaccharide Epitope Involved in the       Hyperacute Rejection Upon Xenotransplantation. " Carbohydrate Research ., 1999, 315, 76.

23.       M. B. Ksebati, H. Guan, Y. Cheng, J. C. Drach, E. R. Kern, and J. Zemlicka,             "Spiropentane Mimics of Nucleosides:Analogues of 2’-Deoxyadenosine and 2’-           Deoxyguanosine. Synthesis of             all Steroisomers, Isomeric Assignment, and Biological   Activity." J. Org. Chem., 2000, 65,     11280-1290.

24.       M. B. Ksebati, Y. L. Qiu, and J. Zemlicka, "Synthesis of (Z)- And (E)-9-[(2-  Hydroxyethylidene)-cycopropyl]adenine] - New Methylenecyclopropane Analogues of    Adenosine And Their Substrate Activity For Adenosine Deaminase."  Nucleosides. &         Nucleotides  2000, 19, 31-37.

25.       B. Ksebati, Todd J. Zahn, Markus Eilers, Zhengmao Guo, Matthew Simon, Jeffrey D.           Scholten, Steven O. Smith*, and Richard A. Gibbs* "Evaluation of Isoprenoid Conformation in   Solution and in the Active Site of Protein Farnesyltransferase Using Carbon-13 Labeling in        Conjunction with Solution and Solid State NMR." J. Am. Chem.             Soc, 2000, 122, 7153-7164.

26.       B. Ksebati, Wang R, Corbett TH, Kern ER, Drach JC, Zemlicka J. “Methylene-gem-  difluorocyclopropane analogues of nucleosides: synthesis, cyclopropene-methylenecyclopropane   rearrangement, and biological activity.” J. Med.Chem, 2001, 44, 23, 4019-4022.

27.       B. Ksebati, Jia, Q.; Xie, W.-H.; Zhang, W.; Janczuk, A.; Luo, S.-Z.; Zhang, B.-L.; Cheng, J.-P.;         Wang, P.G.; "Ytterbium(III) triflate-catalyzed electrophilic cyclization of glyoxalate-derived         unsaturated imines" Tetrahedron Lett. 2002, 43, 2339-2342.

28.       B. Ksebati, Chen, Y.-S.; Janczuk, A.; Chen, X.; Wang, J.-Q.; Wang, P. G.  “Expeditious        syntheses of two carbohydrate-linked cisplatin analogs”  Carb. Res. 2002, 337, 1043-1046.

29.       B. Ksebati, Y. Ni, K.K.D. Amarasinghe, and J. Montgomery, "First Total Synthesis and         Stereochemical Definition of Isodomoic Acid G." Org. Lett, 2003 , 5, 20, 3771-3773.

30.       B. Ksebati, JP. Desau;niers, and CS. Chow, " Synthesis of 15n-enriched pseudouridine         derivatives.” Org Lett. 2003 , 5(22, 4093-6.

31.       B. Ksebati, Santosh B. Mhaske, Mark N. Prichard, John C.

            Drach, Jiri Zemlicka.” Phosphonate Analogues of Cyclopropavir Phosphates and Their

            E-isomers. Synthesis and Antiviral Activity.” Bioorg Med Chem. 2009 , 17(11), 3892–3899.


32.          B. Ksebati, Dajena Tomco, Sara Schmitt, Mary Jane Heeg, Q. Ping Dou, Cláudio N. Verani.”        Effects of tethered ligands and of metal oxidation state on the interactions of cobalt complexes with the 26S proteasome.”  Journal of Inorganic Biochemistry ,105 (2011) 17591766.


 33.     Appi Reddy Mandhapati †, Takayuki Kato †, Takahiko Matsushita †, Bashar Ksebati †, Andrea Vasella ‡, Erik C. Böttger §, and David Crich *† Fluorine-Decoupled Carbon Spectroscopy for the Determination of Configuration at Fully Substituted, Trifluoromethyl- and Perfluoroalkyl-Bearing Carbons: Comparison with 19F–1H Heteronuclear Overhauser Effect Spectroscopy. J. Org. Chem., 2015, 80 (3), pp 1754–1763.     

Citation Index

  •  Sum of the Times Cited [?] :1023Sum of Times Cited without self-citations [?] :1008Citing Articles [?] :930Citing Articles without self-citations [?] :921Average Citations per Item [?] :23.79h-index [?] :20