Jinsheng Zhang
Jinsheng Zhang received a Ph.D. degree in auditory neurophysiology at University of Fribourg in Switzerland in 1997. He is a tenured full Professor in the Department of Otolaryngology, School of Medicine and the Department of Communication Sciences & Disorders, College of Liberal Arts and Sciences, Wayne State University. He is the Vice Chair for Research and Research Director of the Department of Otolaryngology at Wayne State University School of Medicine. He is the director of the Laboratories of Tinnitus and Auditory Neuroscience Research. His research interests encompass neural mechanisms underlying noise- and blast-induced tinnitus, tinnitus-related traumatic brain injury, brain neuromodulation with sound, electrical stimulation, light and pharmacological agents to treat tinnitus and related neurological disorders, multi-structure electrophysiological recordings, cross-modality neural plasticity, and auditory prostheses. Over the years, he has served as principal investigator on NIH-, DOD-, NSF-, and private agencies-funded projects, and has 80 publications, holds 3 patents, and has trained 40 residents, postdocs, Ph.D. students and other trainees. He was invited to speak at several international tinnitus conferences including Asian-Pacific International Tinnitus Symposium, International Tinnitus Seminar, Tinnitus Research Initiative International Meeting, International Association of Physician in Audiology, and DOD International Tinnitus Conference. He serves as reviewers for a number of scientific journals, as well as federal, international and private funding agencies. He also serves as Associate Editor of JMIHI, Journal of Medical Imaging and Health Informatics, guest associate editor of the Journal of American Audiology, board officer of the Lions Hearing Center of Michigan, Scientific advisory committee of the XIth International Tinnitus Seminars in Berlin, and the Scientific Research Advisory Committee of the American Tinnitus Association. He is recently elected as the Chair of the Scientific Advisory Committee (consisting of international tinnitus experts) of the American Tinnitus Association. He also organized a special issue on tinnitus, with contributions from experts around the world. This issue appears in the journal Frontiers in Neurology (http://journal.frontiersin.org/researchtopic/tinnitus-an-attempt-to-confront-the-diverse-models-2633).
Research Interest/Area of Expertise
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Neural mechanisms of noise- and blast-induced tinnitus, hearing loss, related traumatic brain injury (TBI), brain modulation with sound, electrical/optical/chemical stimulation, large-scale brain recording, auditory proesthesis.
Education – Degrees, Licenses, Certifications
- BS 1985 Biology Hebei Normal University, China
- MS 1988 Physiology Hebei Normal University, China
- PhD 1997 Neurophysiology University of Fribourg, Switzerland
- PostDoc 2000 Auditory Neuroscience Wayne State University
- MS Coursework Electronics & Computer Control Systems Wayne State University
Selected Publications
ORIGINAL ARTICLES:
1. Zhang, J.S., Sun, Z.Y. and Tian, G. (1988) A study on the mechanism of motor learning and memory mediated by cerebellum in rats. Chi. Physiol. Soci. Comm., 1: 45.
2. Zhang, J.S., Tian, G., Sun, Z.Y. and Guan, Z.S. (1990) The role of cerebellum in motor learning and memory in rats. J. Chi. Electronic Microscopy, 9(3):16.
3. Vischer, M.W., Bajo, V., Zhang, J.S., Häusler, R. and Rouiller, E.M. (1995) Activity elicited in the auditory pathway of the rat by electrical stimulation of the cochlea. J. Oto-Rhino-Laryngol., 57: 305-309.
4. Zhang, J.S., Haenggeli, A., Tempini, A., Vischer, M.W., Moret, V. and Rouiller, E.M. (1996) Electrically induced Fos-like immunoreactivity (FLI) in the auditory pathway of the rats: effects of survival time, duration and intensity of stimulation. Brain Res. Bullet., 39 (2): 75-82.
5. Haenggeli, A., Vischer, M.W., Zhang, J.S., Pelizzone, M. and Rouiller, E.M. (1996) Animal model of cochlear implant and CIS strategy. Aktuelle Probleme der Otorhinolaryngologie, ORL, 19: 211-217.
6. Vischer, M.W., Bajo, V., Zhang, J.S., Calciati, E., Haenggeli, A. and Rouiller, E.M. (1997) Single unit activity in the inferior colliculus of the rat elicited by electrical stimulation of the cochlea. Audiology, 36: 202-227.
7. Vischer, M.W., Haenggeli, A., Zhang, J.S., Pelizzone, M., Häusler, R. and Rouiller, E.M. (1997) Effects of high-frequency electrical stimulation of the auditory nerve in an animal model of cochlear implants. Am. J. Otol., 18: S27-S29.
8. Zhang, J.S., Vischer, M.W., Moret, V., Roulin, C. and Rouiller, E.M. (1998) Antibody-dependent Fos-like immunoreactivity (FLI) in the auditory pathway of the rat in response to electric stimulation of the cochlea. J. Brain Res., 39(1): 21-35.
9. Haenggeli, A., Zhang, J.S., Vischer, M.W., Pelizzone, M. and Rouiller, E.M. (1998) Electrically evoked compound action potential (ECAP) of the cochlear nerve in response to pulsatile electrical stimulation of the cochlea in the rat: effects of stimulation at high rates. Audiology, 37: 353-371.
10. Kaltenbach, J.A., Godfrey, D.A., Neumann, J.B., McCaslin, D.L., Afman, C.E. and Zhang, J.S. (1998) Changes in spontaneous neural activity in the dorsal cochlear nucleus following exposure to intense sound: independents from threshold shift. Hear. Res., 124: 78-84.
11. Zhang, J.S. and Kaltenbach, J.A. (1998) Increases in spontaneous activity in the dorsal cochlear nucleus of the rat following exposure to high intensity sound. Neurosci. lett., 250: 197-200.
12. Kaltenbach, J.A., Zhang, J.S. and Afman, C.E. (2000) Plasticity of spontaneous neural activity in the dorsal cochlear nucleus after intense sound exposure. Hear. Res.,147: 282-292.
13. Zhang, J.S. and Kaltenbach, J.A. (2000) Modulation of spontaneous activity by muscarinic receptors in the rat dorsal cochlear nucleus in vivo. Hear. Res., 140: 7-17.
14. Bahu, S., Kaltenbach, J.A., Zhang, J.S., Khariwhala, S., Afman, C. and Hnatiuk M. (2001) Expression of c-fos in the dorsal cochlear nucleus as a function of stimulus frequency in the hamster. Neurosci. Res. Comm., 29: 107-117.
15. Chang, H., Chen, K., Kaltenbach, J.A., Zhang, J.S. and Godfrey, D.A. (2002) Effects of acoustic trauma on dorsal cochlear nucleus neuron activity in slices. Hear. Res., 164: 59-68.
16. Kaltenbach, J.A., Rachel, J.D., Mathog, T.A., Zhang, J.S., Falzarano, P.R. and Lewandowski, M. (2002) Cisplatin-induced hyperactivity in the dorsal cochlear nucleus and its relation to outer hair loss: implications for an understanding of tinnitus. J. Neurophysiol., 88: 699-714.
17. Zacharek, M.A., Kaltenbach, J.A., Mathog, T. A. and Zhang, J.S. (2002) Effects of cochlear ablation on noise induced hyperactivity in the hamster dorsal cochlear nucleus: implications on the origin of noise-induced tinnitus. Hear. Res., 172: 137-144.
18. Chen, Y.M., Zhang, J.S, Duan, X.L. (2003) Changes of microvascular architecture, ultrastructure and permeability of rat jejunal villi at different ages. World J. Gastroenterol., 9: 795-799.
19. Zhang J.S., Kaltenbach J.A., Wang J. and Bronchti G. (2003) Changes in [14C]-2-deoxyglucose uptake in the auditory pathway of hamsters previously exposed to intense sound exposure. Hear. Res., 185:13-21.
20. Zhang J.S., Kaltenbach J.A., Wang J. and Kim S.A. (2003) Fos-like immunoreactivity (FLI) in auditory and non-auditory brain structures of hamsters previously exposed to intense sound exposure. Exp. Brain. Res., 153:655-600.
21. Kaltenbach J.A., Zacharek M.A., Zhang J.S. and Frederick S. (2004) Recordings of activity in the dorsal cochlear nucleus of hamsters previously tested for tinnitus following intense sound exposure. Neurosci. Lett., 355:121-125.
22. Kaltenbach J.A. and Zhang J.S. (2004) In vivo optical imaging of tone-evoked activity in the dorsal cochlear nucleus using voltage sensitive dye. J. Neurosci. Res., 78(6):908-917.
23. Zhang, J.S., Kaltenbach, J.A., Godfrey, D.A. and Wang, J. (2006) Origin of hyperactivity in the hamster dorsal cochlear nucleus following intense sound exposure. J. Neurosci. Res., 84:819-831.
24. Kaltenbach, J.A. and Zhang, J.S. (2007) Intense sound induced plasticity in the dorsal cochlear nucleus of rats: Evidence for cholinergic receptor upregulation. Hear. Res., 226(1-2):232-43.
25. Zhang, J.S. and Guan Z.L. (2007) Pathways involved in somatosensory electrical modulation of dorsal cochlear nucleus activity. Brain Res., 1184:121-131.
26. Seidman MD, De Ridder D, Elisevich K, Bowyer SM , Darrat I, Dria J, Stach B, Jiang Q, Tepley N, Ewing J, Seidman M, Zhang J.S. (2008) Direct Electrical Stimulation of Heschl's Gyrus for Tinnitus Treatment. The Laryngoscope, 118;(3):491-500.
27. Hoa, M., Guan, Z.L., Auner, G., and Zhang, J.S. (2008) Tonotopic properties in the inferior colliculus following multichannel electrical stimulation of the dorsal cochlear nucleus of guinea pigs. Otolaryngology-Head and Neck Surgery, 139:152-155.
28. Zhang, J.S. and Guan Z.L. (2008) Modulatory effects of somatosensory electrical stimulation on neural activity of the dorsal cochlear nucleus of hamsters. J. Neurosci. Res., 86:1178-1187.
29. Zhang, J.S., Guan, Z.G., Zhang, X.G., Beydoun, H., Zhang, J., Seidman, M., Elisevich, K., Bowyer, S., Jiang, Q. and J Moran (2010) Cortical modulation of tinnitus and its neural correlates. N.Z.Med.J, 123, 77-88.
30. Talukder, M.I., P Siy, P., Auner, G.W. and Zhang, J.S. (2009) The methodology of probe design with the better resolution and less resistive donut probe to achieve the best performance. J. Bionic Eng. 6:239-245.
31. Zhang, J.S. Zhang, X.G. (2010) Electrical stimulation of the dorsal cochlear nucleus induces hearing in rats. Brain Res. 1311:37-50.
32. Zhang, J.S., Zhang, Y.P. and Zhang, X.G. (2011) Auditory cortex electrical stimulation suppresses tinnitus in rats. J Assoc Res Otolaryngol. 12(2):185-201.
33. Zhu, Na, Wu, Sean. and Zhang, Jinsheng. (2011) Development of three-dimensional time reversal algorithm to locate tinnitus-related hyperactive neurons. The Journal of the Acoustical Society of America 10/2011; 130(4):2453.
34. Ereifej E, Khan S, Newaz G, Zhang J.S., Auner G, VandeVord P. (2011) Characterization of astrocyte reactivity and gene expression on biomaterials for neural electrodes. J. Biomed Mater Res., 99(1):141-150.
35. John, J., Li, Y.F., Zhang, J.S., Loeb, J. and Xu, Y. (2011) Microfabrication of 3D neural probes with combined electrical and chemical interfaces. J Micromech. Micoeng., 21:105011 (11pp).
36. Mao, J., Pace, E., Pierozynski, P., Bobak, L., Kou, Z. F., VandeVord, P., Shen, Y.M., Haacke, M., Zhang, X.G., Zhang, J.S. (2012) Blast-induced tinnitus and hearing loss in rats: Behavioral and imaging assays. J. Neurotrauma, 29:430-444.
37. Luo, H., Zhang, X.G. Nation, J. Pace, E., Lepczyk, L. and Zhang, J.S. (2012) Tinnitus Suppression by Electrical Stimulation of the Rat Dorsal Cochlear Nucleus. Neurosci Lett. 26;522(1):16-20
38. Ereifei, ES, Khan S, Newaz G, Zhang, J.S., Auner GW and VandeVord PJ (2013) Comparative Assessment of Iridium Oxide and Platinum Alloy Wires using an in vitro Glial Scar Assay. Biomedical Microdevices. 15(6):917-924.
39. Church MW, Zhang, J.S., Langford MM, and Perring SA (2013) “Ecstasy” Enhances Noise-Induced Hearing Loss. Hearing Research. 302C:96-106.
40. Pace, E. and Zhang, J.S. (2013) Noise-Induced Tinnitus Using Individualized Gap Detection Analysis and Its Relationship with Hyperacusis, Anxiety, and Spatial Cognition. PloS ONE PloS ONE 8(9): e75011.
41. Kim, E.G., John, J.K., Tu, H., Zheng, Q., Loeb, J., and Zhang, J.S., and Xu, Y. (2013) A hybrid silicon-parylene neural probe with locally flexible regions.
42. Gao, Yayue; Cao, Shuyang; Qu, Tianshu; Wu, Xihong; Li, Haifeng; Zhang, Jinsheng; Li, Liang. (2014) Voice-Associated Static Face Image Releases Speech from Informational Masking. PsyCh Journal. 3(2)113-120.
43. Mahmood, G., Mei, Z.G., Hojjat, H., Pace, P., and Zhang, J.S. (2014) Therapeutic Effect of Sildenafil on Blast-Induced Tinnitus and Auditory Impairment. Neurosci. 269:367-382.
44. Luo, H., Pace, E., Zhang, X. and Zhang, J.S. (2014) Blast Induced Tinnitus and Spontaneous Firing Changes in the Rat Dorsal Cochlear Nucleus. J. Neurosci Res. 92(11)1466-1477.
45. Hao Luo, Xueguo Zhang, Edward Pace and Jinsheng Zhang (2014) “Blast-Induced Tinnitus and Hearing Loss and Their Related Neural activity Changes in the Rat Inferior Colliculus”. Neurosci Lett. 580:47-51.
46. Gao, Y., Cao, S., Qu, T., Wu, X., Li, H., Zhang, J.S., Li, L. (2014) Voice-Associated Static Face Image Releases Speech from Informational Masking, PsyCh Journal. 3:113-120.
47. Zhang, J.S., Liu, B., Luo, H., Kim, E., Tu, Hongen, Pace, E, Bao, S.W., and Xu, Y. (2015) Targeted Optogenetic Corticofugal Modulation to Suppress Tinnitus. Bio-Medical Materials Engineering- ICBE2288-THC.
48. Xin-Xing Wang, Yan Jin, Hui Sun, Chunlei Ma, Jinsheng Zhang, Ming Wang, Lin Chen (2015) Characterization of rebound depolarization in neurons of the rat's medial geniculate body in vitro. Neuroscience Bulletin.
49. Xin-Xing Wang, Yan Jin, Bin Luo, Jing-Wu Sun, Jinsheng Zhang, Ming Wang, Lin Chen (2015) Sodium salicylate potentiates the GABAb-GIRK pathway to suppress rebound depolarization in neurons of the rat's medial geniculate body. Hearing Research. 332: 104-112.
50. Eric Kim, Hongen Tu, Hao Luo, Bin Liu, Shaowen Bao, Jinsheng Zhang and Yong Xu (2015) 3D silicon neural probe with integrated optical fibers for optogenetic modulation. Lab on a Chip, Royal Society of Chemistry, DOI: 10.1039/C4LC01472C.
51. Wang, X.X., Jin, Y., Luo, B., Sun, J.W., Zhang, J., Wang, M., and Chen, L. (2016a). Sodium salicylate potentiates the GABAB-GIRK pathway to suppress rebound depolarization in neurons of the rat's medial geniculate body. Hear Res 332, 104-112.
52. Wang, X.X., Jin, Y., Sun, H., Ma, C., Zhang, J., Wang, M., and Chen, L. (2016b). Characterization of Rebound Depolarization in Neurons of the Rat Medial Geniculate Body In Vitro. Neurosci Bull 32, 16-26.
53. Zhang, J.S., Luo, H., Pace, Ed. And Liu B. (2016) Psychophysical and Neural Correlates of Noised-Induced Tinnitus in Animals: Intra- and Inter-Auditory and Non-Auditory Brain Structure Studies. Hearing Res. 334:7-19.
54. Pace, E., Luo, H., Bobian, M., Panekkad, A., Zhang., X, Zhang, H., and Zhang, J.S. (2016). A Conditioned Behavioral Paradigm for Assessing Onset and Lasting Tinnitus in Rats. PLoS One. e0166346. doi: 10.1371/journal.pone.0166346. PubMed PMID: 27835697.
55. Luo, H., Pace, E. & Zhang, J.S. (2016) Blast-induced tinnitus and hyperactivity in the auditory cortex of rats. Neuroscience 340, 515-520.
56. Liu, B., Kim, E., Meggo, A., Gandhi, S., Luo, H., Kallakuri, S., Xu, Y., Zhang, J. (2017). Enhanced biocompatibility of neural probes by integrating microstructures and delivering anti-inflammatory agents via microfluidic channels. J Neural Eng, 14(2), 026008. doi:10.1088/1741-2552/aa52dc.
REVIEW ARTICLES:
57. Kaltenbach, J.A., Zhang, J.S. Finlayson, P. (2005) Tinnitus as a plastic phenomenon and its possible neural underpinnings in the dorsal cochlear nucleus. Hear. Res., 206(1-2):200-26.
58. Zhang, J.S., Guan, Z.L., Ramachandran, V., Danford, J., Hoa, M., Pace, E., Seidman, M.D., Elisevich, K., Bowyer, S.M., Jiang, Q. (2008) Electrical Modulation of Tinnitus-Related Activity. Seminars in Hearing, 29: 313-326.
59. Godfrey, D.A., Mikesell, N.L., Godfrey, T.G., Fulcomer, A.B., Kong, W., Godfrey, M.A., Kaltenbach, J.A., and Zhang, J.S. (2008) Effects of high-intensity sound exposure on neurotransmitter chemistry in the central auditory system. Seminars in Hearing, 29: 259-269.
60. Zhang, J.S. (2013) Auditory Cortex Stimulation to Suppress Tinnitus: Mechanisms and Strategies. Hear Res. 295(1-2):38-57.
61. Cacace, A.T., Brozoski, T., Berkowitz, B., Bauer, C., Odintsov, B., Bergkvist, M., Castracane, J., Zhang, J.S. and Holt, A.G. (2014) Manganese enhanced magnetic resonance imaging (MEMRI): A unique imaging biomarker to study tinnitus. Hear Res. 311:49-62.
62. Zhang, J.S. and Pace, Edward (2016) Drug Treatments for Tinnitus: What’s New? North American Brain Injury Association (NABIS) - Brain Injury Professional.
BOOK CHAPTERS:
63. Zhang, J.S. and Sun, Z.Y. (1992) Sensory organs, Chapter 11, In: Test Questions and Answers of Human Histology and Anatomy, Duan, X.L. and Sun, Z.Y. (Ed.), Educational Science Press, Beijing, pp.129-138.
64. Zhang, J.S. (1995) The psychophysiological principles of vocal music arts, Chapter 9, In: Vocal Music Course, Wang, M.J. (Ed.), People’s Music Press, Beijing, pp. 153-163.
65. Zhang, J.S., Vischer, M.W., Haenggeli, C.A. and Rouiller, E.M. (1997) Responses of the auditory nerve to high rate pulsatile electrical stimulation: comparison between normal and deafened rats, Chapter 53, In: Acoustical Signal Processing in the Central Auditory System, Syka, J. (Ed.), Plenum Press, New York, pp. 577-583. (Book chapter, invited).
66. Kaltenbach, J.A., Heffner, H.E., Zhang, J.S., Mathog, T.A. and Zacharek, M.A. (2001) Neurophysiological mechanisms of noise-induced tinnitus, Chapter 23, Noise Induced Hearing Loss: Basic Mechanisms, Prevention and Control, Henderson, D., Prasher, D., Kopke, R., Salvi, R., Hamernik, R. (Eds.), NRN Publications, London, pp.153-168. (Book chapter, invited).
67. Kaltenbach, J.A., Zhang, J.S., Zacharek, M.A. (2004) Neural correlates of tinnitus. In: Tinnitus: Theory and Management. Edited by J.B.Snow B.C. Decker Publishers, Inc., pp 141-161.
68. Zhang, J.S., Hao Luo and Edward Pace (2015) “Animal Model of Tinnitus”, Chapter 4, In: Tinnitus – Diagnosis/Treatment, Shulman et al (Ed.), Thieme Publishers, New York.
69. Zhang, J.S. and Shulman, A. (2015) “Inflammation and Tinnitus”, Chapter 5, In: Tinnitus – Diagnosis/Treatment, Shulman et al (Ed.), Thieme Publishers, New York.
70. Seidman, M.D. and Zhang, J.S. (2015) “Electrical Stimulation of the Brain and Neuromodulation”, Chapter 60, In: Tinnitus – Diagnosis/Treatment, Shulman et al (Ed.), Thieme Publishers, New York.
PROCEEDING ARTICLES:
71. Godfrey, D.A., Mikesell, N.L., Godfrey, T.G., Fulcomer, A.B., Kong, W., Godfrey, M.A., Zhang, J.S. and Kaltenbach, J.A. (1999) Chemistry in the hamster dorsal cochlear nucleus after loud tone exposure. Proc. VIth Intl. Tinn. Sem., 6: 203-208.
72. Chen, K., Chang, H., Zhang, J.S., Kaltenbach, J.A. and Godfrey, D.A. (1999) Altered spontaneous activity in rat dorsal cochlear nucleus following loud tone exposure. Proc. VIth Intl. Tinn. Sem., 6: 212-217.
73. Bowyer, S.M., Seidman, M.D., Moran, J.E., Mason, K.M., Jiang, Q., Elisevich, K., Zhang, J.S., Tepley, N. (2008) Coherence analysis of brain activity associated with tinnitus. In: Proceedings of the 16th International Conference on Biomagnetism. Sapporo, Japan, August 25-29, 2008, pp. 163-166.
74. Tan, Z.B., Wang, L.Y., Wang, H., Zhang, X.G. and Zhang, J.S. (2010) Modeling for the Impact of Anesthesia on Neural Activity in the Auditory System. In: 2010 Southern Biomedical Engineering Conference proceedings.
75. Li, Y.F., Jessin, J., Zhang, X.G., Zhang, J.S., Loeb, L., Xu, Y. (2010) 3D neural probes with combined electrical and chemical interfaces. Proceedings to a solid-state sensors, actuators and microsystems workshop, pp 134-137.
76. Zhang, J.S., Bin Liu, Hao Luo, Eric Kim, Hongen Tu, Edward Pace, Shaowen Bao, and Yong Xu (2014) Targeted Optogenetic Corticofugal Modulation to Suppress Tinnitus. Bio-Medical Materials and Engineering.
PERIODICAL ARTICLES:
77. Zhang, J.S. (2005) Suppressing tinnitus with electrical stimulation. Tinnitus Today, 30(1):11.
78. Zhang, J.S. (2006) Electrical suppressing of tinnitus. Tinnitus Today. 39 (1): 11-12.
79. Zhang, J.S. (2007) Electrical suppression of tinnitus. Tinnitus Today. 32 (3): 14-15.
80. Kwong, K., Zhang, X.G., Pace, E., Zhang, Y.P., Moran, J. and Zhang, J.S. (2010) Mechanisms underlying acoustic masking of tinnitus. Tinnitus Today. 35 (2): 13-17.
Courses taught
AUD 6400 Anatomy & Physiology of the Auditory System
AUD 7410 Psychoacoustics
PSL 7660 Advanced Neurophysiology