Jinsheng Zhang, Ph.D.

Jinsheng Zhang, Ph.D.

Department

Communication Sciences and Disorders; Otolaryngology-Head and Neck Surgery

Jinsheng Zhang received a Ph.D. degree in auditory neurophysiology at University of Fribourg in Switzerland in 1997. He is a tenured full Professor in the Department of Otolaryngology, School of Medicine and the Department of Communication Sciences & Disorders, College of Liberal Arts and Sciences, Wayne State University. He is the Vice Chair for Research and Research Director of the Department of Otolaryngology at Wayne State University School of Medicine. He is the director of the Laboratories of Tinnitus and Auditory Neuroscience Research. His research interests encompass neural mechanisms underlying noise- and blast-induced tinnitus, tinnitus-related traumatic brain injury, brain neuromodulation with sound, electrical stimulation, light and pharmacological agents to treat tinnitus and related neurological disorders, multi-structure electrophysiological recordings, cross-modality neural plasticity, and auditory prostheses. Over the years, he has served as principal investigator on NIH-, DOD-, NSF-, and private agencies-funded projects, and has nearly 90 publications, holds 3 patents, and has trained nearly 50 residents, postdocs, Ph.D. students and other trainees. He was invited to speak at several international tinnitus conferences including Asian-Pacific International Tinnitus Symposium, International Tinnitus Seminar, Tinnitus Research Initiative International Meeting, International Association of Physician in Audiology, and DOD International Tinnitus Conference. He serves as reviewers for a number of scientific journals, as well as federal, international and private funding agencies. He also serves as Associate Editor of JMIHI, Journal of Medical Imaging and Health Informatics, guest associate editor of the Journal of American Audiology, board officer of the Lions Hearing Center of Michigan, Scientific advisory committee of the XIth International Tinnitus Seminars in Berlin, and the Scientific Research Advisory Committee of the American Tinnitus Association. He served as the Chair of the Scientific Advisory Committee (consisting of international tinnitus experts) of the American Tinnitus Association. He also organized a special issue on tinnitus, with contributions from experts around the world. This issue appears in the journal Frontiers in Neurology. He is currently serving on the Board of the American Tinnitus Association. He and Dr. Grant Searchfield are editing a volume: The Behavioral Neuroscience of Tinnitus, published by Springer.

Research interest(s)/area of expertise

• Neural mechanisms of noise- and blast-induced tinnitus, hearing loss, related traumatic brain injury (TBI), brain modulation with sound, electrical/optical/chemical stimulation, large-scale brain recording, auditory proesthesis. 

  Dr. Zhang has extensive background in conducting animal research in the areas of auditory electrophysiology, tinnitus (noise and blast-induced) and auditory prosthesis. His expertise spans broad technical domains with specific interests and direct experience in tinnitus and electrical suppression of tinnitus, cochlear and auditory brainstem implants, neuroanatomy, auditory electrophysiology, optical imaging, neuropharmacology, behavioral assays of hearing and tinnitus, psychophysics, and magnetic resonance imaging (MRI) including, susceptibility weighted imaging (SWI), diffusion tensor imaging (DTI), MR spectroscopy (MRS), and manganese-enhanced MRI (MEMRI). Recently, his research has expanded to conducting tinnitus research directly in human subjects.

Research

Research Highlights

• Dr. Zhang's ResearchGate
• Podcast on Neuromodulation to Suppress Tinnitus (or Youtube)
• Auditory Cortex Electrical Stimulation Suppresses Tinnitus in Rats
• Blast-Induced Tinnitus - MRI Study
• Blast-Induced Tinnitus - MEMRI Study
• Dr. Zhang's Team Develop Behavioral Tool for Understanding Tinnitus in Rats & Article
• Postdoc Dr. Hao Luo Receives a New Grant Award on Tinnitus Research via Cochlear Stimulation

 Other Activities

• Drs. Zhang and Norena Hosted a Special Issue: Tinnitus - An Attempt to Confront the Diverse Models
• Dr. Zhang will lead scientific committee for tinnitus association
• Report by Dr. Zhang as ATA-SAC chair: Research and Treatment Developments from the 9th International Tinnitus Research Initiative Tinnitus Conference
• Participation in DOD-Hearing Center of Excellence's Pharmaceutical Interventions for Hearing Loss: Noise Committee  
• Hyperacusis-Related Research Activity
• Dr. Zhang to address worldwide conference on tinnitus

In the News

• Preventing noise-induced hearing loss, tinnitus in soldiers
• Congress Mandates Better Reporting of Tinnitus Among United States Military
• The Noise in Your Head
• The Sound That Comes From Nowhere
• Crains Detroit, Appointments News

Mentoring Activity

Student Awards

Collaborators

Lab Gallery

Education

• BS 1985 Biology Hebei Normal University, China
• MS 1988 Physiology Hebei Normal University, China
• PhD 1997 Neurophysiology University of Fribourg, Switzerland
• PostDoc 2000 Auditory Neuroscience Wayne State University
• MS Coursework Electronics & Computer Control Systems Wayne State University

Awards and grants

• GRANT SUPPORT

  National Institute on Deafness and Other Communication Disorders
  The Department of Defense
  Tinnitus Research Consortium
  American Tinnitus Association
  Action on Hearing Loss
  Del Harder Research Foundation
  Tinnitus Research Initiative
  National Science Foundation 

  AWARDS

  2011 Co-recipient (with Prof. Sean Wu) of President’s Research Enhancement Program in Physical Sciences (WSU). This award carries research funds of $100,000 for a study “Tinnitus Diagnosis and Treatment via Innovative Acoustic/Neural Stimulus and Imaging Technologies”.

  2010 Nominee of 2011 President’s Award for Excellence in Teaching, WSU.

Selected publications

Journal Articles (last five years):

Zhang, J.S. (2013) Auditory Cortex Stimulation to Suppress Tinnitus: Mechanisms and Strategies. Hear Res. 295(1-2):38-57.

Pace, E. and Zhang, J.S. (2013) Noise-Induced Tinnitus Using Individualized Gap Detection Analysis and Its Relationship with Hyperacusis, Anxiety, and Spatial Cognition. PloS ONE PloS ONE 8(9): e75011.

Kim, E.G., John, J.K., Tu, H., Zheng, Q., Loeb, J., and Zhang, J.S., and Xu, Y. (2013) A hybrid silicon-parylene neural probe with locally flexible regions.

Gao, Yayue; Cao, Shuyang; Qu, Tianshu; Wu, Xihong; Li, Haifeng; Zhang, Jinsheng; Li, Liang. (2014) Voice-Associated Static Face Image Releases Speech from Informational Masking. PsyCh Journal. 3(2)113-120.

Cacace, A.T., Brozoski, T., Berkowitz, B., Bauer, C., Odintsov, B., Bergkvist, M., Castracane, J., Zhang, J.S. and Holt, A.G. (2014) Manganese enhanced magnetic resonance imaging (MEMRI): A unique imaging biomarker to study tinnitus. Hear Res. 311:49-62.

Mahmood, G., Mei, Z.G., Hojjat, H., Pace, P., and Zhang, J.S. (2014) Therapeutic Effect of Sildenafil on Blast-Induced Tinnitus and Auditory Impairment. Neurosci. 269:367-382.

Luo, H., Pace, E., Zhang, X. and Zhang, J.S. (2014) Blast Induced Tinnitus and Spontaneous Firing Changes in the Rat Dorsal Cochlear Nucleus. J. Neurosci Res. 92(11)1466-1477.

Hao Luo, Xueguo Zhang, Edward Pace and Jinsheng Zhang (2014) “Blast-Induced Tinnitus and Hearing Loss and Their Related Neural activity Changes in the Rat Inferior Colliculus”. Neurosci Lett. 580:47-51.

Gao, Y., Cao, S., Qu, T., Wu, X., Li, H., Zhang, J.S., Li, L. (2014) Voice-Associated Static Face Image Releases Speech from Informational Masking, PsyCh Journal. 3:113-120.

Zhang, J.S., Liu, B., Luo, H., Kim, E., Tu, Hongen, Pace, E, Bao, S.W., and Xu, Y. (2015) Targeted Optogenetic Corticofugal Modulation to Suppress Tinnitus. Bio-Medical Materials Engineering- ICBE2288-THC.

Xin-Xing Wang, Yan Jin, Bin Luo, Jing-Wu Sun, Jinsheng Zhang, Ming Wang, Lin Chen (2015) Sodium salicylate potentiates the GABAb-GIRK pathway to suppress rebound depolarization in neurons of the rat's medial geniculate body. Hearing Research. 332: 104-112.

Eric Kim, Hongen Tu, Hao Luo, Bin Liu, Shaowen Bao, Jinsheng Zhang and Yong Xu (2015) 3D silicon neural probe with integrated optical fibers for optogenetic modulation. Lab on a Chip, Royal Society of Chemistry, DOI: 10.1039/C4LC01472C.

Wang, X.X., Jin, Y., Luo, B., Sun, J.W., Zhang, J., Wang, M., and Chen, L. (2016a). Sodium salicylate potentiates the GABAB-GIRK pathway to suppress rebound depolarization in neurons of the rat's medial geniculate body. Hear Res 332, 104-112.

Wang, X.X., Jin, Y., Sun, H., Ma, C., Zhang, J., Wang, M., and Chen, L. (2016b). Characterization of Rebound Depolarization in Neurons of the Rat Medial Geniculate Body In Vitro. Neurosci Bull 32, 16-26.

Zhang, J.S., Luo, H., Pace, Ed. And Liu B. (2016) Psychophysical and Neural Correlates of Noised-Induced Tinnitus in Animals: Intra- and Inter-Auditory and Non-Auditory Brain Structure Studies. Hearing Res. 334:7-19.

Pace, E., Luo, H., Bobian, M., Panekkad, A., Zhang., X, Zhang, H., and Zhang, J.S. (2016). A Conditioned Behavioral Paradigm for Assessing Onset and Lasting Tinnitus in Rats. PLoS One. e0166346. doi: 10.1371/journal.pone.0166346. PubMed PMID: 27835697.

Zhang, J.S. and Pace, Edward (2016) Drug Treatments for Tinnitus: What’s New? North American Brain Injury Association (NABIS) - Brain Injury Professional. Volume 13, issue 1.

Luo, H., Pace, E. & Zhang, J.S. (2016) Blast-induced tinnitus and hyperactivity in the auditory cortex of rats. Neuroscience 340, 515-520.

Liu, B., Kim, E., Meggo, A., Gandhi, S., Luo, H., Kallakuri, S., Xu, Y., Zhang, J. (2017). Enhanced biocompatibility of neural probes by integrating microstructures and delivering anti-inflammatory agents via microfluidic channels. J Neural Eng, 14(2), 026008. doi:10.1088/1741-2552/aa52dc.

Ouyang J, Pace E, Lepczyk L, Kaufman M, Zhang J, Perrine SA, Zhang J (2017) Blast-Induced Tinnitus and Elevated Central Auditory and Limbic Activity in Rats: A Manganese-Enhanced MRI and Behavioral Study. Scientific reports 7, 4852, doi:10.1038/s41598-017-04941-w.

Ahsan, S. F., Luo, H., Zhang, J., Kim, E. & Xu, Y. An animal model of deep brain stimulation for treating tinnitus: A proof of concept study. Laryngoscope 128, 1213-1222, doi:10.1002/lary.26876 (2018).

Zhao ZG, Kim E, Luo H, Zhang JS, Xu Y (2018) Flexible deep brain neural probes based on a parylene tube structure. J Micromech Microeng. 2018;28(1). doi: ARTN 01501210.1088/1361-6439/aa9d61. PubMed PMID: WOS:000417990400002.

Kallakuri S, Pace E, Lu H, Luo H, Cavanaugh J, Zhang J (2018) Time course of blast-induced injury in the rat auditory cortex. PLoS One. 2018;13(2):e0193389. doi: 10.1371/journal.pone.0193389. PubMed PMID: 29489862.

Zhao, Han; Wang, Li; Chen, Liang; Huang, Yi-Na; Zhang, Jinsheng; Sun, Wei; Salvi, Richard; Wang, Ming; Chen, Lin (2018) Temporary conductive hearing loss in early life impairs spatial memory of rats in adulthood. Brain and Behavior. Brain and Behavior, DOI: 10.1002/brb3.1004

Masri S, Zhang LS, Luo H, Pace E, Zhang J, Bao S (2018), Blast Exposure Disrupts the Tonotopic Frequency Map in the Primary Auditory Cortex. Neuroscience 379:428-434.

Weihua Wang, Wang W, Zinsmaier AK, Firestone E, Lin R, Yatskievych TA, Yang S, Zhang J, Bao S (2018), Blocking Tumor Necrosis Factor-Alpha Expression Prevents Blast-Induced Excitatory/Inhibitory Synaptic Imbalance and Parvalbumin-Positive Interneuron Loss in the Hippocampus. J Neurotrauma 35:2306-2316.

Syed F. Ahsan, Anika Miggo, Hossein Mahboubi, Hao Luo, Jinsheng Zhang (2018) Effects of Transtympanic Gadolineum on Hearing in Rats. Larynogscope.

Geng R, Furness DN, Muraleedharan CK, Zhang J, Dabdoub A, Lin V, Xu S. The microRNA-183/96/182 Cluster is Essential for Stereociliary Bundle Formation and Function of Cochlear Sensory Hair Cells. Scientific reports. 2018. p. 18022.

Weihua Wang, Li S. Zhang, Alexander K. Zinsmaier, Genevieve Patterson, Emily Jean Leptich, Savannah L. Shoemaker, Tatiana A. Yatskievych, Robert Gibboni, Edward Pacec, Hao Luo, Jinsheng Zhang, Sungchil Yang, Shaowen Bao (2019) Neuroinflammation Mediates Noise-Induced Synaptic Imbalance and Tinnitus in Rodent Models. PLoS Biology, 17, e3000307.

Zhang, J.S. (2019) Blast-Induced Tinnitus: Animal Models. The Journal of the Acoustical Society of America (JASA).

Currently teaching

• PSL 7660 Advanced Neurophysiology

Courses taught

AUD 6400 Anatomy & Physiology of the Auditory System

AUD 7410 Psychoacoustics

Other qualifications directly relevant to courses taught

NIH Biosketch